PMID- 10579915
OWN - NLM
STAT- MEDLINE
DCOM- 19991230
LR  - 20131121
IS  - 0014-4827 (Print)
IS  - 0014-4827 (Linking)
VI  - 253
IP  - 1
DP  - 1999 Nov 25
TI  - Ribosomal S6 kinase signaling and the control of translation.
PG  - 100-9
AB  - The highly homologous 40S ribosomal protein S6 kinases (S6K1 and S6K2) play a key
      role in the regulation of cell growth by controlling the biosynthesis of
      translational components which make up the protein synthetic apparatus, most
      notably ribosomal proteins. In the case of S6K1, at least eight phosphorylation
      sites are believed to mediate kinase activation in a hierarchical fashion.
      Activation is initiated by phosphatidylinositide-3OH kinase (PI3K)-mediated
      phosphorylation of key residues in the carboxy-terminus of the kinase, allowing
      phosphorylation of a critical residue residing in the activation loop of the
      catalytic domain by phosphoinositide-dependent kinase 1 (PDK1). The kinases
      responsible for phosphorylating the carboxy-terminal sites have yet to be
      identified. Additionally, S6 kinases are under the control of the PI3K relative, 
      mammalian Target Of Rapamycin (mTOR), which may serve an additional function as a
      checkpoint for amino acid availability. In this review we set out to discuss the 
      present state of knowledge regarding upstream signaling components which have
      been implicated in the control of S6K1 activation and the role of the kinase in
      controlling cell growth through regulating ribosome biogenesis at the
      translational level.
CI  - Copyright 1999 Academic Press.
FAU - Dufner, A
AU  - Dufner A
AD  - Friedrich Miescher Institute, Maulbeerstrasse 66, Basel, CH-4058, Switzerland.
FAU - Thomas, G
AU  - Thomas G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Exp Cell Res
JT  - Experimental cell research
JID - 0373226
RN  - 0 (Isoenzymes)
RN  - EC 2.7.11.1 (Ribosomal Protein S6 Kinases)
RN  - EC 2.7.11.13 (Protein Kinase C)
RN  - W36ZG6FT64 (Sirolimus)
SB  - IM
MH  - Cell Division
MH  - Cell Size
MH  - Enzyme Activation
MH  - Isoenzymes/metabolism
MH  - *Protein Biosynthesis
MH  - Protein Kinase C/metabolism
MH  - Ribosomal Protein S6 Kinases/*metabolism
MH  - *Signal Transduction
MH  - Sirolimus/pharmacology
RF  - 97
EDAT- 1999/12/02 00:00
MHDA- 1999/12/02 00:01
CRDT- 1999/12/02 00:00
PHST- 1999/12/02 00:00 [pubmed]
PHST- 1999/12/02 00:01 [medline]
PHST- 1999/12/02 00:00 [entrez]
AID - 10.1006/excr.1999.4683 [doi]
AID - S0014-4827(99)94683-9 [pii]
PST - ppublish
SO  - Exp Cell Res. 1999 Nov 25;253(1):100-9. doi: 10.1006/excr.1999.4683.