PMID- 10579907
OWN - NLM
STAT- MEDLINE
DCOM- 19991230
LR  - 20091119
IS  - 0014-4827 (Print)
IS  - 0014-4827 (Linking)
VI  - 253
IP  - 1
DP  - 1999 Nov 25
TI  - Phospholipase C-gamma as a signal-transducing element.
PG  - 15-24
AB  - A ubiquitous signaling event in hormonal responses is the phospholipase C
      (PLC)-catalyzed hydrolysis of phosphatidylinositol 4, 5-bisphosphate to produce
      the metabolite second messenger molecules inositol 1,4,5-trisphosphate and
      diacylglycerol. The former provokes a transient increase in intracellular free
      Ca(2+), while the latter serves as a direct activator of protein kinase C. In
      tyrosine kinase-dependent signaling pathways this reaction is mediated by the
      PLC-gamma isozymes. These are direct substrates of many tyrosine kinases in a
      wide variety of cell types. The mechanism of PLC-gamma activation involves its
      association with and phosphorylation by receptor and non-receptor tyrosine
      kinases, as well as interaction with specialized adaptor molecules and, perhaps, 
      other second messenger molecules. However, the biochemistry of PLC-gamma is at a 
      more advanced state than a clear understanding of exactly how this signaling
      element functions in the generation of a mitogenic response.
CI  - Copyright 1999 Academic Press.
FAU - Carpenter, G
AU  - Carpenter G
AD  - Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, 
      Tennessee, 37232-0146, USA. Graham.Carpenter@mcmail.vanderbilt.edu
FAU - Ji, Q s
AU  - Ji Qs
LA  - eng
GR  - CA75195/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - Exp Cell Res
JT  - Experimental cell research
JID - 0373226
RN  - 0 (Isoenzymes)
RN  - 0 (Receptors, Antigen)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
RN  - EC 3.1.4.- (Type C Phospholipases)
RN  - EC 3.1.4.3 (Phospholipase C gamma)
SB  - IM
MH  - Enzyme Activation
MH  - Fertilization/physiology
MH  - Isoenzymes/*metabolism
MH  - Lymphocytes/immunology
MH  - Phospholipase C gamma
MH  - Receptor Protein-Tyrosine Kinases/metabolism
MH  - Receptors, Antigen/metabolism
MH  - *Signal Transduction
MH  - Type C Phospholipases/*metabolism
RF  - 123
EDAT- 1999/12/02 00:00
MHDA- 1999/12/02 00:01
CRDT- 1999/12/02 00:00
PHST- 1999/12/02 00:00 [pubmed]
PHST- 1999/12/02 00:01 [medline]
PHST- 1999/12/02 00:00 [entrez]
AID - 10.1006/excr.1999.4671 [doi]
AID - S0014482799946712 [pii]
PST - ppublish
SO  - Exp Cell Res. 1999 Nov 25;253(1):15-24. doi: 10.1006/excr.1999.4671.