PMID- 10578172
OWN - NLM
STAT- MEDLINE
DCOM- 20000229
LR  - 20051116
IS  - 1350-9047 (Print)
IS  - 1350-9047 (Linking)
VI  - 6
IP  - 11
DP  - 1999 Nov
TI  - Caspase knockouts: matters of life and death.
PG  - 1043-53
AB  - Apoptosis, the seemingly counter-intuitive act of physiological cell suicide, is 
      accomplished by an evolutionarily conserved death program that is centered on the
      activation of a group of intracellular cysteine proteases known as caspases. It
      is now clear that both extra- and intra-cellular stimuli induce apoptosis by
      triggering the activation of these otherwise latent proteases in a process that
      culminates in caspase-mediated disintegration of cellular contents and their
      subsequent absorption by neighboring cells. While many elegant in vitro studies
      have demonstrated the requirement of caspase activities for the execution of
      most, if not all, apoptosis, the precise contribution of individual caspases in
      vivo and how they functionally relate to each other remain poorly elucidated.
      Fortunately, the generation of various caspase deficient mice through gene
      targeting has provided a unique window of opportunity to definitely examine the
      physiological function of these caspases in vivo. As the list of caspase
      knockouts grows, we considered it was time to review what we have been learned,
      from these studies about the exact role of individual caspases in mediating
      apoptotic events. We will also provide our prediction on the direction of future 
      studies in this ever-growing field of caspases.
FAU - Zheng, T S
AU  - Zheng TS
AD  - Section of Immunobiology, Yale University School of Medicine, New Haven,
      Connecticut 06510, USA. timothy_zheng@biogen.com
FAU - Hunot, S
AU  - Hunot S
FAU - Kuida, K
AU  - Kuida K
FAU - Flavell, R A
AU  - Flavell RA
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Cell Death Differ
JT  - Cell death and differentiation
JID - 9437445
RN  - EC 3.4.22.- (Caspases)
SB  - IM
MH  - Animals
MH  - Caspases/genetics/immunology/*physiology
MH  - Forecasting
MH  - Mice
MH  - Mice, Knockout
MH  - Mitochondria/physiology
RF  - 65
EDAT- 1999/12/01 09:00
MHDA- 2000/03/04 09:00
CRDT- 1999/12/01 09:00
PHST- 1999/12/01 09:00 [pubmed]
PHST- 2000/03/04 09:00 [medline]
PHST- 1999/12/01 09:00 [entrez]
AID - 10.1038/sj.cdd.4400593 [doi]
PST - ppublish
SO  - Cell Death Differ. 1999 Nov;6(11):1043-53. doi: 10.1038/sj.cdd.4400593.