PMID- 10577520
OWN - NLM
STAT- MEDLINE
DCOM- 19991222
LR  - 20190516
IS  - 0741-5400 (Print)
IS  - 0741-5400 (Linking)
VI  - 66
IP  - 5
DP  - 1999 Nov
TI  - Regulation of CD 163 on human macrophages: cross-linking of CD163 induces
      signaling and activation.
PG  - 858-66
AB  - CD163 is a member of the group B scavenger receptor cysteine-rich (SRCR)
      superfamily. This study describes aspects of the tissue distribution, the
      regulation of expression, and signal transduction after cross-linking of this
      receptor at the cell surface of macrophages. CD163 showed an exclusive expression
      on resident macrophages (e.g., red pulp macrophages, alveolar macrophages). The
      expression was inducible on monocyte-derived macrophages by glucocorticoids but
      not by interleukin-4 (IL-4), granulocyte-macrophage colony-stimulating factor
      (GM-CSF), and interferon-gamma. The combination of IL-4 or GM-CSF with
      glucocorticoids resulted in a further increase. Subcellular analysis of alveolar 
      macrophages by immunoelectron microscopy showed a plasma membrane localization of
      the antigen. Cross-linking of CD163 with monoclonal antibody induced a protein
      tyrosine kinase-dependent signal that resulted in (1) slow-type calcium
      mobilization, (2) inositol triphosphate production, and (3) secretion of IL-6 and
      GM-CSF. The data suggest a function for the SRCR-superfamily receptor CD163 in
      the regulation of inflammatory processes by macrophages.
FAU - Van den Heuvel, M M
AU  - Van den Heuvel MM
AD  - Department of Cell Biology & Immunology, Faculty of Medicine, Academic Hospital, 
      Vrije Universiteit, Amsterdam, The Netherlands.
FAU - Tensen, C P
AU  - Tensen CP
FAU - van As, J H
AU  - van As JH
FAU - Van den Berg, T K
AU  - Van den Berg TK
FAU - Fluitsma, D M
AU  - Fluitsma DM
FAU - Dijkstra, C D
AU  - Dijkstra CD
FAU - Dopp, E A
AU  - Dopp EA
FAU - Droste, A
AU  - Droste A
FAU - Van Gaalen, F A
AU  - Van Gaalen FA
FAU - Sorg, C
AU  - Sorg C
FAU - Hogger, P
AU  - Hogger P
FAU - Beelen, R H
AU  - Beelen RH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Leukoc Biol
JT  - Journal of leukocyte biology
JID - 8405628
RN  - 0 (Antigens, CD)
RN  - 0 (Antigens, Differentiation, Myelomonocytic)
RN  - 0 (CD163 antigen)
RN  - 0 (Cross-Linking Reagents)
RN  - 0 (Cytokines)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Receptors, Immunologic)
RN  - 0 (Receptors, Scavenger)
SB  - IM
MH  - Animals
MH  - *Antigens, CD
MH  - Antigens, Differentiation, Myelomonocytic/genetics/*metabolism
MH  - Cross-Linking Reagents
MH  - Cytokines/biosynthesis
MH  - Humans
MH  - Immunoblotting
MH  - Intracellular Fluid
MH  - *Macrophage Activation
MH  - Macrophages/immunology/*metabolism
MH  - Macrophages, Alveolar/metabolism
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - *Receptors, Cell Surface
MH  - Receptors, Immunologic/genetics/metabolism
MH  - Receptors, Scavenger
MH  - *Signal Transduction
MH  - Subcellular Fractions/metabolism
MH  - Tissue Distribution
MH  - Transfection
MH  - Tumor Cells, Cultured
MH  - U937 Cells
EDAT- 1999/11/30 00:00
MHDA- 1999/11/30 00:01
CRDT- 1999/11/30 00:00
PHST- 1999/11/30 00:00 [pubmed]
PHST- 1999/11/30 00:01 [medline]
PHST- 1999/11/30 00:00 [entrez]
AID - 10.1002/jlb.66.5.858 [doi]
PST - ppublish
SO  - J Leukoc Biol. 1999 Nov;66(5):858-66. doi: 10.1002/jlb.66.5.858.