PMID- 10577388
OWN - NLM
STAT- MEDLINE
DCOM- 19991208
LR  - 20191210
IS  - 1093-9946 (Print)
IS  - 1093-4715 (Linking)
VI  - 4
DP  - 1999 Dec 1
TI  - Plasma membrane calcium ATPases as critical regulators of calcium homeostasis
      during neuronal cell function.
PG  - D869-82
AB  - The plasma membrane calcium ATPases (PMCAs) are ubiquitously expressed proteins
      that couple the extrusion of calcium across the plasma membrane with the
      hydrolysis of ATP. In mammals, four separate genes encode distinct PMCA isoforms.
      Complex patterns of alternative RNA splicing generate additional isoform
      variability. Functionally, the PMCAs were originally assigned the role of
      maintaining basal levels of intracellular calcium. Recent evidence, however, is
      expanding the role of the PMCAs as important participants in dynamic Ca2+
      regulation and as crucial players of Ca2+ export during normal and pathological
      conditions. This review highlights recent advances made on the biology of the
      PMCAs within the context of neuronal development, cellular responses to external 
      stimuli and cell survival. Particular emphasis is placed on the role of the PMCAs
      in vestibular and auditory functions, localized calcium signaling in
      photoreceptor synaptic terminals and calcium-mediated cell death.
FAU - Garcia, M L
AU  - Garcia ML
AD  - Ludwig Institute for Cancer Research, University of California San Diego, 9500
      Gilman Drive, La Jolla, CA.
FAU - Strehler, E E
AU  - Strehler EE
LA  - eng
GR  - GM58710/GM/NIGMS NIH HHS/United States
GR  - NS10436/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
DEP - 19991201
PL  - United States
TA  - Front Biosci
JT  - Frontiers in bioscience : a journal and virtual library
JID - 9709506
RN  - 0 (Cation Transport Proteins)
RN  - 0 (Free Radicals)
RN  - 0 (Neurotransmitter Agents)
RN  - EC 3.6.3.8 (Plasma Membrane Calcium-Transporting ATPases)
RN  - EC 7.2.2.10 (Calcium-Transporting ATPases)
RN  - SY7Q814VUP (Calcium)
SB  - IM
SB  - S
MH  - Animals
MH  - Calcium/*metabolism
MH  - Calcium-Transporting ATPases/genetics/*metabolism/*physiology
MH  - Cation Transport Proteins
MH  - Cell Death
MH  - Cell Differentiation
MH  - Cell Survival
MH  - Cochlea/growth & development/physiology
MH  - Free Radicals/metabolism
MH  - Hair Cells, Auditory/cytology
MH  - Homeostasis
MH  - Mice
MH  - Mice, Knockout
MH  - Mice, Mutant Strains
MH  - Neurons/cytology/*metabolism/physiology
MH  - Neurotransmitter Agents/metabolism
MH  - Photoreceptor Cells/metabolism
MH  - Plasma Membrane Calcium-Transporting ATPases
MH  - Seizures/metabolism
MH  - Synapses/metabolism
MH  - Vestibule, Labyrinth/growth & development/physiology
RF  - 98
EDAT- 1999/11/30 00:00
MHDA- 1999/11/30 00:01
CRDT- 1999/11/30 00:00
PHST- 1999/11/30 00:00 [pubmed]
PHST- 1999/11/30 00:01 [medline]
PHST- 1999/11/30 00:00 [entrez]
AID - 10.2741/garcia [doi]
PST - epublish
SO  - Front Biosci. 1999 Dec 1;4:D869-82. doi: 10.2741/garcia.