PMID- 10576740
OWN - NLM
STAT- MEDLINE
DCOM- 19991214
LR  - 20190619
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 286
IP  - 5445
DP  - 1999 Nov 26
TI  - Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses,
      leukocyte homeostasis, and to preclude autoimmunity.
PG  - 1735-8
AB  - Apoptosis can be triggered by members of the Bcl-2 protein family, such as Bim,
      that share only the BH3 domain with this family. Gene targeting in mice revealed 
      important physiological roles for Bim. Lymphoid and myeloid cells accumulated, T 
      cell development was perturbed, and most older mice accumulated plasma cells and 
      succumbed to autoimmune kidney disease. Lymphocytes were refractory to apoptotic 
      stimuli such as cytokine deprivation, calcium ion flux, and microtubule
      perturbation but not to others. Thus, Bim is required for hematopoietic
      homeostasis and as a barrier to autoimmunity. Moreover, particular death stimuli 
      appear to activate apoptosis through distinct BH3-only proteins.
FAU - Bouillet, P
AU  - Bouillet P
AD  - The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria
      3050, Australia.
FAU - Metcalf, D
AU  - Metcalf D
FAU - Huang, D C
AU  - Huang DC
FAU - Tarlinton, D M
AU  - Tarlinton DM
FAU - Kay, T W
AU  - Kay TW
FAU - Kontgen, F
AU  - Kontgen F
FAU - Adams, J M
AU  - Adams JM
FAU - Strasser, A
AU  - Strasser A
LA  - eng
GR  - CA43540/CA/NCI NIH HHS/United States
GR  - CA80188/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (Apoptosis Regulatory Proteins)
RN  - 0 (Bcl-2-Like Protein 11)
RN  - 0 (Bcl2l11 protein, mouse)
RN  - 0 (Carrier Proteins)
RN  - 0 (Membrane Proteins)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Proto-Oncogene Proteins c-bcl-2)
SB  - IM
MH  - Animals
MH  - *Apoptosis
MH  - Apoptosis Regulatory Proteins
MH  - Autoimmune Diseases/etiology
MH  - *Autoimmunity
MH  - B-Lymphocytes/physiology
MH  - Bcl-2-Like Protein 11
MH  - Carrier Proteins/*physiology
MH  - Cells, Cultured
MH  - Crosses, Genetic
MH  - Female
MH  - Gene Targeting
MH  - Glomerulonephritis/etiology
MH  - Hematopoietic Stem Cells/physiology
MH  - Homeostasis
MH  - Leukocyte Count
MH  - Leukocytes/*physiology
MH  - Male
MH  - *Membrane Proteins
MH  - Mice
MH  - Mice, Transgenic
MH  - *Proto-Oncogene Proteins
MH  - Proto-Oncogene Proteins c-bcl-2/physiology
MH  - Signal Transduction
MH  - T-Lymphocyte Subsets/physiology
EDAT- 1999/11/27 00:00
MHDA- 1999/11/27 00:01
CRDT- 1999/11/27 00:00
PHST- 1999/11/27 00:00 [pubmed]
PHST- 1999/11/27 00:01 [medline]
PHST- 1999/11/27 00:00 [entrez]
AID - 8026 [pii]
AID - 10.1126/science.286.5445.1735 [doi]
PST - ppublish
SO  - Science. 1999 Nov 26;286(5445):1735-8. doi: 10.1126/science.286.5445.1735.