PMID- 10574771
OWN - NLM
STAT- MEDLINE
DCOM- 20000511
LR  - 20191210
IS  - 0960-9822 (Print)
IS  - 0960-9822 (Linking)
VI  - 9
IP  - 22
DP  - 1999 Nov 18
TI  - Human CED-6 encodes a functional homologue of the Caenorhabditis elegans
      engulfment protein CED-6.
PG  - 1347-50
AB  - The rapid engulfment of apoptotic cells is a specialized innate immune response
      used by organisms to remove apoptotic cells. In mammals, several receptors that
      recognize apoptotic cells have been identified; molecules that transduce signals 
      from these receptors to downstream cytoskeleton molecules have not been found,
      however [1] [2] [3]. Our previous analysis of the engulfment gene ced-6 in
      Caenorhabditis elegans has suggested that CED-6 is an adaptor protein that
      participates in a signal transduction pathway that mediates the specific
      recognition and engulfment of apoptotic cells [1]. Here, we describe our
      isolation and characterization of a human cDNA encoding a protein, hCED-6, with
      strong sequence similarity to C. elegans CED-6. As is the case with the worm
      protein, hCED-6 contains a phosphotyrosine-binding (PTB) domain and potential
      Src-homology domain 3 (SH3) binding sites. Both CED-6 and hCED-6 contain a
      predicted coiled-coil domain in the middle region. The hCED-6 protein lacks the
      extended carboxyl terminus found in worm CED-6; this carboxy-terminal extension
      appears not to be essential for CED-6 function in C. elegans, however.
      Overexpression of hCED-6 rescues the engulfment defect of ced-6 mutants in C.
      elegans significantly, suggesting that hCED-6 is a functional homologue of C.
      elegans CED-6. Human ced-6 is expressed widely in most human tissues. Thus,
      CED-6, and the CED-6 signal transduction pathway, might be conserved from C.
      elegans to humans and are present in most, if not all, human tissues.
FAU - Liu, Q A
AU  - Liu QA
AD  - Cold Spring Harbor Laboratory, Laboratory of Immunology, National Institute of
      Allergy and Infectious Disease, National Institute of Health, Cold Spring Harbor,
      Bethesda, 11724, 20892, USA.
FAU - Hengartner, M O
AU  - Hengartner MO
LA  - eng
GR  - GM52540/GM/NIGMS NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Curr Biol
JT  - Current biology : CB
JID - 9107782
RN  - 0 (Apoptosis Regulatory Proteins)
RN  - 0 (CED-6 protein, C elegans)
RN  - 0 (Caenorhabditis elegans Proteins)
RN  - 0 (DNA, Complementary)
RN  - 0 (Helminth Proteins)
RN  - 0 (Phosphoproteins)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Apoptosis
MH  - Apoptosis Regulatory Proteins
MH  - Caenorhabditis elegans/embryology/*genetics/metabolism
MH  - *Caenorhabditis elegans Proteins
MH  - DNA, Complementary/genetics
MH  - Expressed Sequence Tags
MH  - Genetic Complementation Test
MH  - Helminth Proteins/genetics
MH  - Humans
MH  - Molecular Sequence Data
MH  - Open Reading Frames
MH  - Organ Specificity
MH  - Phosphoproteins/*genetics/physiology
MH  - Protein Structure, Tertiary
MH  - RNA, Messenger/analysis
MH  - Sequence Alignment
MH  - Sequence Homology, Amino Acid
MH  - Species Specificity
EDAT- 1999/11/27 09:00
MHDA- 2000/05/16 09:00
CRDT- 1999/11/27 09:00
PHST- 1999/11/27 09:00 [pubmed]
PHST- 2000/05/16 09:00 [medline]
PHST- 1999/11/27 09:00 [entrez]
AID - S0960-9822(00)80061-5 [pii]
AID - 10.1016/s0960-9822(00)80061-5 [doi]
PST - ppublish
SO  - Curr Biol. 1999 Nov 18;9(22):1347-50. doi: 10.1016/s0960-9822(00)80061-5.