PMID- 10574768
OWN - NLM
STAT- MEDLINE
DCOM- 20000511
LR  - 20190728
IS  - 0960-9822 (Print)
IS  - 0960-9822 (Linking)
VI  - 9
IP  - 22
DP  - 1999 Nov 18
TI  - Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of 
      higher inositol polyphosphate kinases.
PG  - 1323-6
AB  - Inositol (1,4,5) trisphosphate (Ins(1,4,5)P(3)) is a well-known messenger
      molecule that releases calcium from intracellular stores. Homologues with up to
      six phosphates have been characterized and recently, homologues with seven or
      eight phosphate groups, including pyrophosphates, have been identified. These
      homologues are diphosphoinositol pentakisphosphate (PP-InsP(5)/InsP(7)) and
      bis(diphospho)inositol tetrakisphosphate (bis-PP-InsP(4)/InsP(8)) [1], the rapid 
      turnover of which [2] is regulated by calcium [2] and adrenergic receptor
      activity [3]. It has been proposed that the high-energy pyrophosphates might
      participate in protein phosphorylation [4]. We have purified InsP(6) kinase [5]
      and PP-InsP(5) kinase [6], both of which display ATP synthase activity,
      transferring phosphate to ADP. Here, we report the cloning of two mammalian
      InsP(6) kinases and a yeast InsP(6) kinase. Furthermore, we show that the yeast
      protein, ArgRIII, is an inositol-polyphosphate kinase that can convert InsP(3) to
      InsP(4), InsP(5) and InsP(6). We have identified a new family of highly conserved
      inositol-polyphosphate kinases that contain a newly identified, unique consensus 
      sequence.
FAU - Saiardi, A
AU  - Saiardi A
AD  - Department of Neuroscience, Johns Hopkins University School of Medicine,
      Baltimore, 21205, USA.
FAU - Erdjument-Bromage, H
AU  - Erdjument-Bromage H
FAU - Snowman, A M
AU  - Snowman AM
FAU - Tempst, P
AU  - Tempst P
FAU - Snyder, S H
AU  - Snyder SH
LA  - eng
SI  - GENBANK/AF177144
SI  - GENBANK/AF177145
GR  - DA00074/DA/NIDA NIH HHS/United States
GR  - MH18501/MH/NIMH NIH HHS/United States
GR  - P30 CA08748/CA/NCI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Curr Biol
JT  - Current biology : CB
JID - 9107782
RN  - 0 (Fungal Proteins)
RN  - 0 (Ihpk1 protein, mouse)
RN  - 0 (Inositol Phosphates)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Recombinant Fusion Proteins)
RN  - 0 (Saccharomyces cerevisiae Proteins)
RN  - 148077-18-3 (1-diphosphoinositol pentakisphosphate)
RN  - 8L70Q75FXE (Adenosine Triphosphate)
RN  - EC 2.7.1.- (ARG82 protein, S cerevisiae)
RN  - EC 2.7.1.- (Phosphotransferases (Alcohol Group Acceptor))
RN  - EC 2.7.1.127 (Inositol 1,4,5-trisphosphate 3-kinase)
RN  - EC 2.7.4.- (Phosphotransferases (Phosphate Group Acceptor))
RN  - EC 2.7.4.- (diphosphoinositol pentakisphosphate kinase)
RN  - EC 2.7.4.21 (KCS1 protein, S cerevisiae)
RN  - EC 2.7.4.21 (inositol hexakisphosphate kinase)
SB  - IM
MH  - Adenosine Triphosphate/metabolism
MH  - Amino Acid Sequence
MH  - Animals
MH  - Brain/enzymology
MH  - Consensus Sequence
MH  - Female
MH  - Fungal Proteins/chemistry/*metabolism
MH  - Inositol Phosphates/*biosynthesis
MH  - Male
MH  - Mice
MH  - Molecular Sequence Data
MH  - *Multigene Family
MH  - Nerve Tissue Proteins/isolation & purification/metabolism
MH  - Organ Specificity
MH  - Phosphotransferases (Alcohol Group Acceptor)/chemistry
MH  - Phosphotransferases (Phosphate Group Acceptor)/chemistry/isolation &
      purification/*metabolism
MH  - Recombinant Fusion Proteins/metabolism
MH  - *Saccharomyces cerevisiae Proteins
MH  - Sequence Alignment
MH  - Sequence Homology, Amino Acid
EDAT- 1999/11/27 09:00
MHDA- 2000/05/16 09:00
CRDT- 1999/11/27 09:00
PHST- 1999/11/27 09:00 [pubmed]
PHST- 2000/05/16 09:00 [medline]
PHST- 1999/11/27 09:00 [entrez]
AID - S0960-9822(00)80055-X [pii]
AID - 10.1016/s0960-9822(00)80055-x [doi]
PST - ppublish
SO  - Curr Biol. 1999 Nov 18;9(22):1323-6. doi: 10.1016/s0960-9822(00)80055-x.