PMID- 10574372
OWN - NLM
STAT- MEDLINE
DCOM- 19991221
LR  - 20190718
IS  - 0959-4965 (Print)
IS  - 0959-4965 (Linking)
VI  - 10
IP  - 12
DP  - 1999 Aug 20
TI  - Genomic organization of the human X11L2 gene (APBA3), a third member of the X11
      protein family interacting with Alzheimer's beta-amyloid precursor protein.
PG  - 2575-8
AB  - Recently we cloned a new member of the X11 protein family, X11L2 (gene symbol
      APBA3) which interacts with Alzheimer's beta-amyloid precursor protein (APP) and 
      has three protein-protein interaction domains, a phosphotyrosine interacting
      domain (PID) and two PDZ. Here, we report the genomic structure and mapping of
      the APBA3. The gene spans about 11 kb and is composed of ten coding exons and one
      untranslated exon. The transcription start site of APBA3 was found in a CpG
      island. About 1.2 kb of the 5'-flanking region was also sequenced, and its
      functional promoter activity was confirmed by transient transfection experiments.
      The APBA3 was localized by the radiation hybrid mapping to chromosome 19.
      Determination of the APBA3 genome structure will facilitate the linkage analysis 
      and search for mutations in the APBA3 in patients with Alzheimer's disease.
FAU - Tanahashi, H
AU  - Tanahashi H
AD  - Division of Demyelinating Disease and Aging, National Institute of Neuroscience, 
      Kodaira, Tokyo, Japan.
FAU - Tabira, T
AU  - Tabira T
LA  - eng
SI  - GENBANK/AB023431
SI  - GENBANK/AB024411
PT  - Journal Article
PL  - England
TA  - Neuroreport
JT  - Neuroreport
JID - 9100935
RN  - 0 (APBA1 protein, human)
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Amyloid beta-Protein Precursor)
RN  - 0 (Nerve Tissue Proteins)
SB  - IM
MH  - Adaptor Proteins, Signal Transducing
MH  - Alzheimer Disease/*genetics/metabolism
MH  - Amyloid beta-Protein Precursor/*metabolism
MH  - Base Sequence
MH  - Chromosome Mapping
MH  - Exons
MH  - *Genome, Human
MH  - Humans
MH  - Introns
MH  - Molecular Sequence Data
MH  - Nerve Tissue Proteins/*genetics/*metabolism
MH  - Restriction Mapping
EDAT- 1999/11/26 00:00
MHDA- 1999/11/26 00:01
CRDT- 1999/11/26 00:00
PHST- 1999/11/26 00:00 [pubmed]
PHST- 1999/11/26 00:01 [medline]
PHST- 1999/11/26 00:00 [entrez]
AID - 10.1097/00001756-199908200-00025 [doi]
PST - ppublish
SO  - Neuroreport. 1999 Aug 20;10(12):2575-8. doi: 10.1097/00001756-199908200-00025.