PMID- 10572048
OWN - NLM
STAT- MEDLINE
DCOM- 20000121
LR  - 20220215
IS  - 0950-1991 (Print)
IS  - 0950-1991 (Linking)
VI  - 126
IP  - 24
DP  - 1999 Dec
TI  - Decoding vectorial information from a gradient: sequential roles of the receptors
      Frizzled and Notch in establishing planar polarity in the Drosophila eye.
PG  - 5725-38
AB  - The Drosophila eye is composed of several hundred ommatidia that can exist in
      either of two chiral forms, depending on position: ommatidia in the dorsal half
      of the eye adopt one chiral form, whereas ommatidia in the ventral half adopt the
      other. Chirality appears to be specified by a polarizing signal with a high
      activity at the interface between the two halves (the 'equator'), which declines 
      in opposite directions towards the dorsal and ventral poles. Here, using genetic 
      mosaics, we show that this polarizing signal is decoded by the sequential use of 
      two receptor systems. The first depends on the seven-transmembrane receptor
      Frizzled (Fz) and distinguishes between the two members of the R3/R4 pair of
      presumptive photoreceptor cells, predisposing the cell that is located closer to 
      the equator and having higher Fz activity towards the R3 photoreceptor fate and
      the cell further away towards the R4 fate. This bias is then amplified by
      subsequent interactions between the two cells mediated by the receptor Notch (N) 
      and its ligand Delta (Dl), ensuring that the equatorial cell becomes the R3
      photoreceptor while the polar cell becomes the R4 photoreceptor. As a consequence
      of this reciprocal cell fate decision, the R4 cell moves asymmetrically relative 
      to the R3 cell, initiating the appropriate chiral pattern of the remaining cells 
      of the ommatidium.
FAU - Tomlinson, A
AU  - Tomlinson A
AD  - Department of Genetics and Development, College of Physicians and Surgeons,
      Columbia University, New York, NY 10032, USA. tomlinson@cuccfa.ccc.columbia.edu
FAU - Struhl, G
AU  - Struhl G
LA  - eng
GR  - 1R01EY12536-01/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Development
JT  - Development (Cambridge, England)
JID - 8701744
RN  - 0 (Calcium-Binding Proteins)
RN  - 0 (Drosophila Proteins)
RN  - 0 (Eye Proteins)
RN  - 0 (Frizzled Receptors)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Jagged-1 Protein)
RN  - 0 (Ligands)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Membrane Proteins)
RN  - 0 (N protein, Drosophila)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Receptors, G-Protein-Coupled)
RN  - 0 (Receptors, Notch)
RN  - 0 (Ser protein, Drosophila)
RN  - 0 (Serrate-Jagged Proteins)
RN  - 0 (delta protein)
RN  - 0 (fz protein, Drosophila)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
RN  - EC 2.7.10.1 (sev protein, Drosophila)
SB  - IM
MH  - Animals
MH  - Animals, Genetically Modified
MH  - Calcium-Binding Proteins
MH  - Cell Polarity
MH  - *Drosophila Proteins
MH  - Drosophila melanogaster/*embryology
MH  - Epistasis, Genetic
MH  - Eye Proteins/genetics/physiology
MH  - Frizzled Receptors
MH  - Gene Dosage
MH  - Intercellular Signaling Peptides and Proteins
MH  - Intracellular Signaling Peptides and Proteins
MH  - Jagged-1 Protein
MH  - Ligands
MH  - Membrane Glycoproteins/genetics/physiology
MH  - Membrane Proteins/genetics/*physiology
MH  - Mosaicism
MH  - Photoreceptor Cells, Invertebrate/*embryology/metabolism
MH  - *Receptor Protein-Tyrosine Kinases
MH  - Receptors, Cell Surface/genetics/*physiology
MH  - Receptors, G-Protein-Coupled
MH  - Receptors, Notch
MH  - Serrate-Jagged Proteins
MH  - Signal Transduction
EDAT- 1999/11/26 00:00
MHDA- 1999/11/26 00:01
CRDT- 1999/11/26 00:00
PHST- 1999/11/26 00:00 [pubmed]
PHST- 1999/11/26 00:01 [medline]
PHST- 1999/11/26 00:00 [entrez]
AID - 10.1242/dev.126.24.5725 [doi]
PST - ppublish
SO  - Development. 1999 Dec;126(24):5725-38. doi: 10.1242/dev.126.24.5725.