PMID- 105715
OWN - NLM
STAT- MEDLINE
DCOM- 19790425
LR  - 20190902
IS  - 0006-2928 (Print)
IS  - 0006-2928 (Linking)
VI  - 16
IP  - 9-10
DP  - 1978 Oct
TI  - Relationship between genetic variation in thermal stability and electrophoretic
      mobility of mouse beta-galactosidase.
PG  - 1007-14
AB  - We have examined the relationships between the genetic determinants for mouse
      beta-galactosidase heat stability and electrophoretic mobility, in order to
      clarify previous reports indicating that a variation for enzyme heat stability is
      restricted to kidney while that for electrophoretic mobility is expressed in all 
      tissues. We find that the two phenotypes show concordant strain distributions and
      cosegregate in genetic crosses. In contrast to a previous report, the thermal
      stability variation is expressed in all tissues, although the absolute rate of
      enzyme inactivation is tissue specific. The evidence supports the notion that a
      single beta-galactosidase structural locus is expressed in all tissues and that
      the differences in enzyme stability between tissues results from
      posttranslational enzyme modification.
FAU - Berger, F G
AU  - Berger FG
FAU - Lusis, A J
AU  - Lusis AJ
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Biochem Genet
JT  - Biochemical genetics
JID - 0126611
RN  - EC 3.2.1.- (Galactosidases)
RN  - EC 3.2.1.23 (beta-Galactosidase)
SB  - IM
MH  - Animals
MH  - Electrophoresis, Polyacrylamide Gel
MH  - Galactosidases/*genetics
MH  - *Genetic Variation
MH  - *Hot Temperature
MH  - Kidney/enzymology
MH  - Mice
MH  - Mice, Inbred Strains/genetics
MH  - Protein Conformation
MH  - Tissue Distribution
MH  - beta-Galactosidase/*genetics
EDAT- 1978/10/01 00:00
MHDA- 1978/10/01 00:01
CRDT- 1978/10/01 00:00
PHST- 1978/10/01 00:00 [pubmed]
PHST- 1978/10/01 00:01 [medline]
PHST- 1978/10/01 00:00 [entrez]
AID - 10.1007/bf00483750 [doi]
PST - ppublish
SO  - Biochem Genet. 1978 Oct;16(9-10):1007-14. doi: 10.1007/bf00483750.