PMID- 10571178
OWN - NLM
STAT- MEDLINE
DCOM- 19991214
LR  - 20131121
IS  - 0092-8674 (Print)
IS  - 0092-8674 (Linking)
VI  - 99
IP  - 4
DP  - 1999 Nov 12
TI  - A novel class of eukaryotic zinc-binding proteins is required for disease
      resistance signaling in barley and development in C. elegans.
PG  - 355-66
AB  - Barley Rar1 is a convergence point in the signaling of resistance to powdery
      mildew, triggered by multiple race-specific resistance (R) genes. Rar1 is shown
      to function upstream of H2O2 accumulation in attacked host cells, which precedes 
      localized host cell death. We isolated Rar1 by map-based cloning. The sequence of
      the deduced 25.5 kDa protein reveals two copies of a 60-amino acid domain, CHORD,
      conserved in tandem organization in protozoa, plants, and metazoa. CHORD defines 
      a novel eukaryotic Zn2+-binding domain. Silencing of the C. elegans
      CHORD-containing gene, chp, results in semisterility and embryo lethality,
      suggesting an essential function of the wild-type gene in nematode development.
      Our findings indicate that plant R genes have recruited a fundamental cellular
      control element for signaling of disease resistance and cell death.
FAU - Shirasu, K
AU  - Shirasu K
AD  - The Sainsbury Laboratory, John Innes Centre, Norwich, United Kingdom.
FAU - Lahaye, T
AU  - Lahaye T
FAU - Tan, M W
AU  - Tan MW
FAU - Zhou, F
AU  - Zhou F
FAU - Azevedo, C
AU  - Azevedo C
FAU - Schulze-Lefert, P
AU  - Schulze-Lefert P
LA  - eng
SI  - GENBANK/AF192261
SI  - GENBANK/AF192262
SI  - GENBANK/AF192263
SI  - GENBANK/AF192264
SI  - GENBANK/AF192465
SI  - GENBANK/AF192466
SI  - GENBANK/AF192467
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cell
JT  - Cell
JID - 0413066
RN  - 0 (Carrier Proteins)
RN  - 0 (DNA, Complementary)
RN  - 0 (Plant Proteins)
RN  - 0 (Rar1 protein, Hordeum vulgare)
RN  - BBX060AN9V (Hydrogen Peroxide)
RN  - J41CSQ7QDS (Zinc)
SB  - IM
SB  - S
MH  - Alleles
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Caenorhabditis elegans/genetics/growth & development/*physiology
MH  - Carrier Proteins/classification/genetics/*physiology
MH  - Cell Death
MH  - Cloning, Molecular
MH  - DNA, Complementary
MH  - Drosophila melanogaster/genetics
MH  - Eukaryotic Cells
MH  - Genes, Plant
MH  - Hordeum/genetics/*physiology
MH  - Humans
MH  - Hydrogen Peroxide/metabolism
MH  - Molecular Sequence Data
MH  - Mutation
MH  - Plant Diseases
MH  - *Plant Proteins
MH  - RNA Splicing
MH  - Sequence Homology, Amino Acid
MH  - *Signal Transduction
MH  - Toxoplasma/genetics
MH  - Transcription, Genetic
MH  - *Zinc
EDAT- 1999/11/26 00:00
MHDA- 1999/11/26 00:01
CRDT- 1999/11/26 00:00
PHST- 1999/11/26 00:00 [pubmed]
PHST- 1999/11/26 00:01 [medline]
PHST- 1999/11/26 00:00 [entrez]
AID - S0092-8674(00)81522-6 [pii]
PST - ppublish
SO  - Cell. 1999 Nov 12;99(4):355-66.