PMID- 10570955
OWN - NLM
STAT- MEDLINE
DCOM- 20000229
LR  - 20191210
IS  - 0014-5793 (Print)
IS  - 0014-5793 (Linking)
VI  - 458
IP  - 3
DP  - 1999 Sep 24
TI  - Specific loss of chondromodulin-I gene expression in chondrosarcoma and the
      suppression of tumor angiogenesis and growth by its recombinant protein in vivo.
PG  - 436-40
AB  - Chondromodulin-I (ChM-I) was previously identified as an angiogenesis inhibitor
      in cartilage. Here, we demonstrated that the level of ChM-I transcripts was
      substantially reduced to 100 or even less in the lower-grade chondrosarcomas, in 
      articular cartilage or other benign cartilage tumors. We implanted human
      chondrosarcoma OUMS-27 cells into nude mice that reproducibly produced tumors
      with cartilaginous matrix. Tumor-induced angiogenesis was evident when the tumors
      were excised 30 days after implantation. However, the local administration of
      recombinant human ChM-I almost completely blocked vascular invasion and tumor
      growth in vivo. Moreover, ChM-I also inhibited the growth of HT-29 colon
      adenocarcinoma in vivo, implying its therapeutic potential for solid tumors.
FAU - Hayami, T
AU  - Hayami T
AD  - Department of Orthopaedic Surgery, Niigata University School of Medicine, Japan.
FAU - Shukunami, C
AU  - Shukunami C
FAU - Mitsui, K
AU  - Mitsui K
FAU - Endo, N
AU  - Endo N
FAU - Tokunaga, K
AU  - Tokunaga K
FAU - Kondo, J
AU  - Kondo J
FAU - Takahashi, H E
AU  - Takahashi HE
FAU - Hiraki, Y
AU  - Hiraki Y
LA  - eng
SI  - GENBANK/AB005999
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Cnmd protein, mouse)
RN  - 0 (Growth Substances)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (Membrane Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Recombinant Proteins)
RN  - 136362-10-2 (CNMD protein, human)
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents/pharmacology
MH  - Bone Neoplasms/blood supply/*genetics/pathology
MH  - Cartilage/pathology
MH  - Chondrosarcoma/blood supply/*genetics/pathology
MH  - Gene Expression Regulation, Neoplastic
MH  - Growth Substances/analysis/*pharmacology
MH  - HT29 Cells
MH  - Humans
MH  - *Intercellular Signaling Peptides and Proteins
MH  - *Membrane Proteins
MH  - Mice
MH  - Mice, Nude
MH  - Neoplasm Transplantation
MH  - Neovascularization, Pathologic/*pathology
MH  - RNA, Messenger/metabolism
MH  - Recombinant Proteins/pharmacology
MH  - Tumor Cells, Cultured
EDAT- 1999/11/26 09:00
MHDA- 2000/03/04 09:00
CRDT- 1999/11/26 09:00
PHST- 1999/11/26 09:00 [pubmed]
PHST- 2000/03/04 09:00 [medline]
PHST- 1999/11/26 09:00 [entrez]
AID - S0014-5793(99)01201-6 [pii]
AID - 10.1016/s0014-5793(99)01201-6 [doi]
PST - ppublish
SO  - FEBS Lett. 1999 Sep 24;458(3):436-40. doi: 10.1016/s0014-5793(99)01201-6.