PMID- 10570912
OWN - NLM
STAT- MEDLINE
DCOM- 20000127
LR  - 20061115
IS  - 1434-5161 (Print)
IS  - 1434-5161 (Linking)
VI  - 44
IP  - 6
DP  - 1999
TI  - Cloning and characterization of the human UDP-N-acetylglucosamine:
      alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IV-homologue
      (hGnT-IV-H) gene.
PG  - 397-401
AB  - A novel human gene determining a polypeptide product of 478 residues with an
      estimated molecular mass of 55 kDa, which has significant homology and structural
      similarity to Bos UDP-N-acetylglucosamine: alpha-1,3-D-mannoside
      beta-1,4-N-acetylglucosaminyltransferase (GnT-IV), was cloned from the commonly
      deleted region in pancreatic cancer at 12q21. The gene is composed of at least
      six exons, and the last three exons cover the open reading frame. Different sized
      transcripts, 3.8-kb in the heart, brain, and fetal brain and 2.8-kb and 1.7-kb in
      the testis were observed by Northern blot analysis. By reverse
      transcription-polymerase chain reaction, expression was also observed in the
      adult brain, liver, and adrenal gland, but not in pancreas. Because of its
      significant homology and structural similarity to Bos GnT-IV, it is potentially
      the gene encoding human GnT-IV or its homologue, which had been one of two genes 
      remaining to be cloned in the human GnT family.
FAU - Furukawa, T
AU  - Furukawa T
AD  - Department of Molecular Pathology, Tohoku University School of Medicine, Sendai, 
      Japan.
FAU - Youssef, E M
AU  - Youssef EM
FAU - Yatsuoka, T
AU  - Yatsuoka T
FAU - Yokoyama, T
AU  - Yokoyama T
FAU - Makino, N
AU  - Makino N
FAU - Inoue, H
AU  - Inoue H
FAU - Fukushige, S
AU  - Fukushige S
FAU - Hoshi, M
AU  - Hoshi M
FAU - Hayashi, Y
AU  - Hayashi Y
FAU - Sunamura, M
AU  - Sunamura M
FAU - Horii, A
AU  - Horii A
LA  - eng
SI  - GENBANK/AB024729
SI  - GENBANK/AB024730
SI  - GENBANK/AB024906
SI  - GENBANK/AB024907
SI  - GENBANK/AB024908
SI  - GENBANK/AB024909
SI  - GENBANK/AB024910
SI  - GENBANK/AB024911
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Hum Genet
JT  - Journal of human genetics
JID - 9808008
RN  - EC 2.4.1.- (N-Acetylglucosaminyltransferases)
RN  - EC 2.4.1.145 (alpha-1,3-mannosylglycoprotein
      beta-1,4-N-acetylglucosaminyltransferase)
SB  - IM
MH  - Adult
MH  - Amino Acid Sequence
MH  - Animals
MH  - Cattle
MH  - Chromosomes, Human, Pair 12/*genetics
MH  - *Cloning, Molecular
MH  - Humans
MH  - Molecular Sequence Data
MH  - N-Acetylglucosaminyltransferases/chemistry/*genetics/metabolism
MH  - Pancreatic Neoplasms/genetics
EDAT- 1999/11/26 00:00
MHDA- 1999/11/26 00:01
CRDT- 1999/11/26 00:00
PHST- 1999/11/26 00:00 [pubmed]
PHST- 1999/11/26 00:01 [medline]
PHST- 1999/11/26 00:00 [entrez]
AID - 10.1007/s100380050186 [doi]
PST - ppublish
SO  - J Hum Genet. 1999;44(6):397-401. doi: 10.1007/s100380050186.