PMID- 10570909
OWN - NLM
STAT- MEDLINE
DCOM- 20000127
LR  - 20141120
IS  - 1434-5161 (Print)
IS  - 1434-5161 (Linking)
VI  - 44
IP  - 6
DP  - 1999
TI  - C16orf5, a novel proline-rich gene at 16p13.3, is highly expressed in the brain.
PG  - 383-7
AB  - A novel gene has been characterized, designated C16orf5, with an unusually high
      content of proline residues (40% over 104 residues) at the N-terminus of the
      protein. The C-terminus of the protein is also cysteine rich with 14 cysteine
      residues present. Analysis using Northern and dot blots showed that the highest
      expression of this gene is in the brain. The gene was located on chromosome 16 at
      band p13.3 by FISH to metaphase chromosomes. Southern blot analysis with a
      human-rodent somatic cell hybrid panel showed a location between the somatic
      hybrid breakpoints 23HA and CY196. This gene comprises at least four exons and an
      open reading frame of 786 bp encoding a predicted protein of 261 amino acids.
      Analysis of this protein using PSORTII predicted a nuclear localization.
FAU - Bhalla, K
AU  - Bhalla K
AD  - Department of Cytogenetics and Molecular Genetics, Women's and Children's
      Hospital, Adelaide, Australia. kbhalla@medicine.adelaide.edu.au
FAU - Eyre, H J
AU  - Eyre HJ
FAU - Whitmore, S A
AU  - Whitmore SA
FAU - Sutherland, G R
AU  - Sutherland GR
FAU - Callen, D F
AU  - Callen DF
LA  - eng
SI  - GENBANK/AF131218
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Hum Genet
JT  - Journal of human genetics
JID - 9808008
RN  - 0 (Apoptosis Regulatory Proteins)
RN  - 0 (CDIP1 protein, human)
RN  - 0 (Nerve Tissue Proteins)
RN  - 9DLQ4CIU6V (Proline)
SB  - IM
MH  - Amino Acid Sequence
MH  - Apoptosis Regulatory Proteins
MH  - Base Sequence
MH  - Brain/*metabolism
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 16
MH  - Gene Expression
MH  - Humans
MH  - Molecular Sequence Data
MH  - Nerve Tissue Proteins/chemistry/*genetics
MH  - Open Reading Frames/*genetics
MH  - Proline/*analysis
EDAT- 1999/11/26 00:00
MHDA- 1999/11/26 00:01
CRDT- 1999/11/26 00:00
PHST- 1999/11/26 00:00 [pubmed]
PHST- 1999/11/26 00:01 [medline]
PHST- 1999/11/26 00:00 [entrez]
AID - 10.1007/s100380050183 [doi]
PST - ppublish
SO  - J Hum Genet. 1999;44(6):383-7. doi: 10.1007/s100380050183.