PMID- 10570007
OWN - NLM
STAT- MEDLINE
DCOM- 19991221
LR  - 20190513
IS  - 0006-3363 (Print)
IS  - 0006-3363 (Linking)
VI  - 61
IP  - 6
DP  - 1999 Dec
TI  - The Kruppel-like core promoter binding protein gene is primarily expressed in
      placenta during mouse development.
PG  - 1586-91
AB  - The human core promoter binding protein (hCPBP) has been identified as a
      DNA-binding protein involved in the regulation of TATA box-less genes like those 
      encoding the pregnancy-specific glycoproteins. Structurally, hCPBP contains three
      zinc fingers in the C-terminal domain, which is highly conserved in a number of
      proteins that constitute the Kruppel-like family of transcription factors. In the
      present work, we report the molecular cloning of the mouse CPBP (mCPBP) and its
      expression pattern during development as well as in adult tissues. The mouse cDNA
      encodes a protein of 283 amino acids that share 94.4% of identity with the hCPBP.
      The highest level of mCPBP transcript was detected in placenta, and its
      expression was lower in total embryos and in adult tissues. We also show by in
      situ hybridization that during embryonic development the mCPBP gene is mainly
      expressed in extra-embryonic structures throughout gestation; essentially no
      specific expression was detected in embryonic tissues. Our data demonstrate that 
      CPBP transcript is enriched in the trophoblastic tissue and strongly suggest that
      its encoded polypeptide regulates target genes involved in placental development 
      and pregnancy maintenance.
FAU - Slavin, D
AU  - Slavin D
AD  - Departamento de Bioquimica Clinica, Facultad de Ciencias Quimicas, Universidad
      Nacional de Cordoba, Argentina.
FAU - Sapin, V
AU  - Sapin V
FAU - Lopez-Diaz, F
AU  - Lopez-Diaz F
FAU - Jacquemin, P
AU  - Jacquemin P
FAU - Koritschoner, N
AU  - Koritschoner N
FAU - Dastugue, B
AU  - Dastugue B
FAU - Davidson, I
AU  - Davidson I
FAU - Chatton, B
AU  - Chatton B
FAU - Bocco, J L
AU  - Bocco JL
LA  - eng
SI  - GENBANK/AF072403
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Biol Reprod
JT  - Biology of reproduction
JID - 0207224
RN  - 0 (KLF6 protein, human)
RN  - 0 (Klf6 protein, mouse)
RN  - 0 (Kruppel-Like Factor 6)
RN  - 0 (Kruppel-Like Transcription Factors)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Trans-Activators)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Cloning, Molecular
MH  - Conserved Sequence
MH  - *Embryonic and Fetal Development
MH  - Female
MH  - *Gene Expression
MH  - Humans
MH  - In Situ Hybridization
MH  - Kruppel-Like Factor 6
MH  - Kruppel-Like Transcription Factors
MH  - Mice
MH  - Molecular Sequence Data
MH  - Placenta/chemistry/*metabolism
MH  - Pregnancy
MH  - *Proto-Oncogene Proteins
MH  - RNA, Messenger/analysis
MH  - Trans-Activators/chemistry/*genetics
MH  - Zinc Fingers
EDAT- 1999/11/26 00:00
MHDA- 1999/11/26 00:01
CRDT- 1999/11/26 00:00
PHST- 1999/11/26 00:00 [pubmed]
PHST- 1999/11/26 00:01 [medline]
PHST- 1999/11/26 00:00 [entrez]
AID - 10.1095/biolreprod61.6.1586 [doi]
PST - ppublish
SO  - Biol Reprod. 1999 Dec;61(6):1586-91. doi: 10.1095/biolreprod61.6.1586.