PMID- 10567687
OWN - NLM
STAT- MEDLINE
DCOM- 19991228
LR  - 20190621
IS  - 0014-5793 (Print)
IS  - 0014-5793 (Linking)
VI  - 461
IP  - 3
DP  - 1999 Nov 19
TI  - Is pantetheinase the actual identity of mouse and human vanin-1 proteins?
PG  - 149-52
AB  - Pantetheinase is an amidohydrolase involved in the dissimilative pathway of CoA, 
      allowing the turnover of the pantothenate moiety. We have determined the
      N-terminal sequence as well as the sequences of a number of tryptic and
      chymotryptic peptides of the protein isolated from pig kidney. These sequence
      stretches were used as probes to search in the SwissProt database and significant
      similarities were found with a GPI-anchored protein (mouse vanin-1, with a
      suggested role in lymphocyte migration), with two putative proteins encoded by
      human cDNAs (VNN1 and VNN2) and with human biotinidase. On the basis of sequence 
      similarity, we propose that vanin-1 and VNN1 should be identified as
      pantetheinase.
FAU - Maras, B
AU  - Maras B
AD  - Dipartimento di Scienze Biochimiche 'A. Rossi Fanelli' and Centro di Biologia
      Molecolare del Consiglio Nazionale delle Ricerche Universita La Sapienza,
      Piazzale Aldo Moro 5, 00185, Rome, Italy. bmaras@axrma.uniroma1.it
FAU - Barra, D
AU  - Barra D
FAU - Dupre, S
AU  - Dupre S
FAU - Pitari, G
AU  - Pitari G
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (GPI-Linked Proteins)
RN  - EC 3.- (Hydrolases)
RN  - EC 3.5.- (Amidohydrolases)
RN  - EC 3.5.1.- (pantetheinase)
RN  - EC 3.5.1.12 (Biotinidase)
RN  - EC 3.5.1.92 (VNN2 protein, human)
SB  - IM
MH  - Amidohydrolases/*chemistry
MH  - Amino Acid Sequence
MH  - Animals
MH  - Biotinidase
MH  - Cell Adhesion Molecules/*chemistry
MH  - GPI-Linked Proteins
MH  - Humans
MH  - Hydrolases
MH  - Kidney/enzymology
MH  - Mice
MH  - Molecular Sequence Data
MH  - Sequence Alignment
MH  - Sequence Analysis, Protein
MH  - Sequence Homology, Amino Acid
MH  - Swine
EDAT- 1999/11/24 00:00
MHDA- 1999/11/24 00:01
CRDT- 1999/11/24 00:00
PHST- 1999/11/24 00:00 [pubmed]
PHST- 1999/11/24 00:01 [medline]
PHST- 1999/11/24 00:00 [entrez]
AID - S0014-5793(99)01439-8 [pii]
AID - 10.1016/s0014-5793(99)01439-8 [doi]
PST - ppublish
SO  - FEBS Lett. 1999 Nov 19;461(3):149-52. doi: 10.1016/s0014-5793(99)01439-8.