PMID- 10567591
OWN - NLM
STAT- MEDLINE
DCOM- 20000106
LR  - 20190508
IS  - 0270-7306 (Print)
IS  - 0270-7306 (Linking)
VI  - 19
IP  - 12
DP  - 1999 Dec
TI  - Disruption of muREC2/RAD51L1 in mice results in early embryonic lethality which
      can Be partially rescued in a p53(-/-) background.
PG  - 8686-93
AB  - muREC2/RAD51L1 is a radiation-inducible gene that regulates cell cycle
      progression. To elucidate the biological function of muREC2/RAD51L1, the gene was
      disrupted in embryonic stem cells by homologous recombination. Mice heterozygous 
      for muREC2/RAD51L1 appear normal and fertile; however, no homozygous pups were
      born after interbreeding of heterozygous mice. Timed pregnancy studies showed
      that homozygous mutant embryos were severely retarded in growth as early as ca. 5
      days gestation (E5.5) and were completely resorbed by E8.5. Mutant blastocyst
      outgrowth was also severely impaired in a double-knockout embryo, but embryonic
      development did progress further in a p53-null background. These results suggest 
      that muREC2/RAD51L1 plays a role in cell proliferation and early embryonic
      development, perhaps through interaction with p53.
FAU - Shu, Z
AU  - Shu Z
AD  - Department of Biological Sciences, University of Delaware, Newark, Delaware
      19716, USA.
FAU - Smith, S
AU  - Smith S
FAU - Wang, L
AU  - Wang L
FAU - Rice, M C
AU  - Rice MC
FAU - Kmiec, E B
AU  - Kmiec EB
LA  - eng
GR  - R01HL58563-01A1/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Mol Cell Biol
JT  - Molecular and cellular biology
JID - 8109087
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Proteins)
RN  - 0 (RAD51B protein, human)
RN  - 0 (Tumor Suppressor Protein p53)
RN  - EC 2.7.7.- (Rad51 Recombinase)
RN  - EC 2.7.7.- (Rad51 protein, mouse)
SB  - IM
MH  - Animals
MH  - Blastomeres/cytology
MH  - Cells, Cultured
MH  - DNA-Binding Proteins/genetics/*physiology
MH  - Embryonic and Fetal Development
MH  - Female
MH  - Gene Deletion
MH  - Gene Targeting
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Inbred CBA
MH  - Phenotype
MH  - Pregnancy
MH  - Proteins/genetics/*physiology
MH  - Rad51 Recombinase
MH  - Recombination, Genetic
MH  - Tumor Suppressor Protein p53/genetics/*physiology
PMC - PMC85012
EDAT- 1999/11/24 00:00
MHDA- 1999/11/24 00:01
CRDT- 1999/11/24 00:00
PHST- 1999/11/24 00:00 [pubmed]
PHST- 1999/11/24 00:01 [medline]
PHST- 1999/11/24 00:00 [entrez]
AID - 10.1128/mcb.19.12.8686 [doi]
PST - ppublish
SO  - Mol Cell Biol. 1999 Dec;19(12):8686-93. doi: 10.1128/mcb.19.12.8686.