PMID- 10567408
OWN - NLM
STAT- MEDLINE
DCOM- 19991229
LR  - 20190508
IS  - 0021-9258 (Print)
IS  - 0021-9258 (Linking)
VI  - 274
IP  - 48
DP  - 1999 Nov 26
TI  - Peroxisome proliferator-induced long chain acyl-CoA thioesterases comprise a
      highly conserved novel multi-gene family involved in lipid metabolism.
PG  - 34317-26
AB  - Long chain acyl-CoA esters are important intermediates in degradation and
      synthesis of fatty acids, as well as having important functions in regulation of 
      intermediary metabolism and gene expression. Although the physiological functions
      for most acyl-CoA thioesterases have not yet been elucidated, previous data
      suggest that these enzymes may be involved in lipid metabolism by modulation of
      cellular concentrations of acyl-CoAs and fatty acids. In line with this, we have 
      cloned four highly homologous acyl-CoA thioesterase genes from mouse, showing
      multiple compartmental localizations. The nomenclature for these genes has
      tentatively been assigned as CTE-I (cytosolic), MTE-I (mitochondrial), and PTE-Ia
      and Ib (peroxisomal), based on the identification of putative targeting signals. 
      Although the various isoenzymes show between 67% and 94% identity at amino acid
      level, each individual enzyme shows a specific tissue expression. Our data
      suggest that all four genes are located within a very narrow cluster on
      chromosome 12 in mouse, similar to a sequence cluster on human chromosome 14,
      which identified four genes homologous to the mouse thioesterase genes. Four
      related genes were also identified in Caenorhabditis elegans, all containing
      putative PTS1 targeting signals, suggesting that the ancestral type I
      thioesterase gene(s) is/are of peroxisomal origin. All four thioesterases are
      differentially expressed in tissues examined, but all are inducible at mRNA level
      by treatment with the peroxisome proliferator clofibrate, or during the
      physiological condition of fasting, both of which conditions cause a perturbation
      in overall lipid homeostasis. These results strongly support the existence of a
      novel multi-gene family cluster of mouse acyl-CoA thioesterases, each with a
      distinct function in lipid metabolism.
FAU - Hunt, M C
AU  - Hunt MC
AD  - Department of Medical Laboratory Sciences, Division of Clinical Chemistry,
      Karolinska Institutet, Huddinge University Hospital, S-141 86 Huddinge, Sweden.
FAU - Nousiainen, S E
AU  - Nousiainen SE
FAU - Huttunen, M K
AU  - Huttunen MK
FAU - Orii, K E
AU  - Orii KE
FAU - Svensson, L T
AU  - Svensson LT
FAU - Alexson, S E
AU  - Alexson SE
LA  - eng
SI  - GENBANK/AF180793
SI  - GENBANK/AF180794
SI  - GENBANK/AF180795
SI  - GENBANK/AF180796
SI  - GENBANK/AF180797
SI  - GENBANK/AF180798
SI  - GENBANK/AF180799
SI  - GENBANK/AF180800
SI  - GENBANK/AF180801
SI  - GENBANK/AF180802
SI  - GENBANK/AF180803
SI  - GENBANK/AF180804
SI  - GENBANK/AH008442
SI  - GENBANK/AH008443
SI  - GENBANK/AH008444
SI  - GENBANK/AH008445
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Biol Chem
JT  - The Journal of biological chemistry
JID - 2985121R
RN  - 0 (Isoenzymes)
RN  - 0 (Peroxisome Proliferators)
RN  - 0 (RNA, Messenger)
RN  - 0 (Recombinant Fusion Proteins)
RN  - 9007-49-2 (DNA)
RN  - EC 1.13.12.- (Luciferases)
RN  - EC 3.1.2.2 (Palmitoyl-CoA Hydrolase)
RN  - HPN91K7FU3 (Clofibrate)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Caenorhabditis elegans/enzymology/genetics
MH  - Clofibrate/pharmacology
MH  - Cloning, Molecular
MH  - Conserved Sequence
MH  - Cytosol/enzymology
MH  - DNA/chemistry/genetics
MH  - Fasting
MH  - Gene Expression Regulation, Enzymologic/drug effects
MH  - Genes
MH  - Humans
MH  - Isoenzymes/genetics
MH  - *Lipid Metabolism
MH  - Luciferases/genetics/metabolism
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Molecular Sequence Data
MH  - Multigene Family/*genetics
MH  - Palmitoyl-CoA Hydrolase/genetics/*metabolism
MH  - Peroxisome Proliferators/*pharmacology
MH  - Peroxisomes/drug effects/enzymology
MH  - Phylogeny
MH  - Promoter Regions, Genetic/genetics
MH  - RNA, Messenger/drug effects/genetics/metabolism
MH  - Recombinant Fusion Proteins/genetics/metabolism
MH  - Sequence Alignment
MH  - Sequence Analysis, DNA
MH  - Sequence Homology, Amino Acid
MH  - Tissue Distribution
MH  - Tumor Cells, Cultured
EDAT- 1999/11/24 00:00
MHDA- 1999/11/24 00:01
CRDT- 1999/11/24 00:00
PHST- 1999/11/24 00:00 [pubmed]
PHST- 1999/11/24 00:01 [medline]
PHST- 1999/11/24 00:00 [entrez]
AID - 10.1074/jbc.274.48.34317 [doi]
PST - ppublish
SO  - J Biol Chem. 1999 Nov 26;274(48):34317-26. doi: 10.1074/jbc.274.48.34317.