PMID- 10566975
OWN - NLM
STAT- MEDLINE
DCOM- 19991130
LR  - 20061115
IS  - 0271-678X (Print)
IS  - 0271-678X (Linking)
VI  - 19
IP  - 11
DP  - 1999 Nov
TI  - Identification of genes differentially expressed in canine vasospastic cerebral
      arteries after subarachnoid hemorrhage.
PG  - 1279-88
AB  - To understand the molecular processes of continuous vasospasm of cerebral
      arteries after subarachnoid hemorrhage, mRNA differential display and screening
      of cDNA expression array were performed to identify genes that are differentially
      expressed in vasospastic arteries of canine two-hemorrhage models. The expression
      levels of 18 genes were found to be upregulated, and those of two genes to be
      downregulated. Of these, 12 represent known genes or homologues of genes
      characterized previously, and the other eight genes are not related to any
      sequences in the databases. The known genes include five upregulated
      inflammation-related genes encoding monocyte chemotactic protein-1, cystatin B,
      inter-alpha-trypsin inhibitor family heavy chain-related protein, serum amyloid A
      protein, and glycoprotein 130, suggesting that inflammatory reaction may be
      involved in the development of cerebral vasospasm. The upregulation of three
      known genes encoding stress-related proteins of vascular endothelial growth
      factor, BiP protein, and growth-arrest and DNA-damage-inducible protein may be
      involved in possible cell survival in the damaged arteries. A full-length cDNA
      for the unknown clone DVS 27, whose expression was most highly upregulated, was
      isolated from the cerebral artery cDNA library by hybridization. Characterization
      of these genes should help to clarify the molecular mechanism of continuous
      cerebral vasospasm after subarachnoid hemorrhage.
FAU - Onda, H
AU  - Onda H
AD  - Department of Cell Biology, Institute for Molecular and Cellular Regulation,
      Gunma University, Maebashi, Japan.
FAU - Kasuya, H
AU  - Kasuya H
FAU - Takakura, K
AU  - Takakura K
FAU - Hori, T
AU  - Hori T
FAU - Imaizumi, T
AU  - Imaizumi T
FAU - Takeuchi, T
AU  - Takeuchi T
FAU - Inoue, I
AU  - Inoue I
FAU - Takeda, J
AU  - Takeda J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Cereb Blood Flow Metab
JT  - Journal of cerebral blood flow and metabolism : official journal of the
      International Society of Cerebral Blood Flow and Metabolism
JID - 8112566
RN  - 0 (DNA, Complementary)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Cerebral Arteries/*metabolism/physiopathology
MH  - DNA, Complementary/analysis/*genetics
MH  - Dogs
MH  - *Gene Expression
MH  - Molecular Sequence Data
MH  - Subarachnoid Hemorrhage/*genetics/metabolism/physiopathology
EDAT- 1999/11/24 00:00
MHDA- 1999/11/24 00:01
CRDT- 1999/11/24 00:00
PHST- 1999/11/24 00:00 [pubmed]
PHST- 1999/11/24 00:01 [medline]
PHST- 1999/11/24 00:00 [entrez]
AID - 10.1097/00004647-199911000-00013 [doi]
PST - ppublish
SO  - J Cereb Blood Flow Metab. 1999 Nov;19(11):1279-88. doi:
      10.1097/00004647-199911000-00013.