PMID- 10565538
OWN - NLM
STAT- MEDLINE
DCOM- 20000124
LR  - 20191024
IS  - 1042-5179 (Print)
IS  - 1026-7913 (Linking)
VI  - 10
IP  - 1
DP  - 1999
TI  - Isolation and characterization of novel CAG repeat containing genes expressed in 
      human brain.
PG  - 1-6
AB  - Neurodegenerative diseases may be caused by expansion of triplet repeats in human
      genes. To identify novel genes with CAG repeats, we screened a human brain cDNA
      library with an oligonucleotide probe. Four of the isolated cDNAs were sequenced,
      analyzed for polymorphisms, chromosomal localization, evolutionary conservation
      and expression. One of the repeats is bi-allelic with 10 triplets (80% of
      chromosomes) and 7 triplets (20% of chromosomes). In one of the genes two CAG
      repeats coding for 10 and 17 glutamines are localized in the same reading frame.
FAU - Zuhlke, C
AU  - Zuhlke C
AD  - Universitat Lubeck, Institut fur Humangenetik, Lubeck, Germany.
FAU - Kiehl, R
AU  - Kiehl R
FAU - Johannsmeyer, A
AU  - Johannsmeyer A
FAU - Grzeschik, K H
AU  - Grzeschik KH
FAU - Schwinger, E
AU  - Schwinger E
LA  - eng
SI  - GENBANK/Y13870
SI  - GENBANK/Y13871
SI  - GENBANK/Z97016
SI  - GENBANK/Z97017
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - DNA Seq
JT  - DNA sequence : the journal of DNA sequencing and mapping
JID - 9107800
SB  - IM
MH  - Animals
MH  - Blotting, Southern
MH  - Brain/*physiology
MH  - Case-Control Studies
MH  - Cats
MH  - Cattle
MH  - Chromosomes, Human
MH  - Cloning, Molecular
MH  - Dogs
MH  - Gene Dosage
MH  - Gene Expression Profiling
MH  - Gene Expression Regulation
MH  - Humans
MH  - Molecular Sequence Data
MH  - Neurodegenerative Diseases/*genetics
MH  - Polymerase Chain Reaction
MH  - Restriction Mapping
MH  - Sequence Homology, Nucleic Acid
MH  - Species Specificity
MH  - Trinucleotide Repeats/*genetics
EDAT- 1999/11/24 09:00
MHDA- 2000/08/12 11:00
CRDT- 1999/11/24 09:00
PHST- 1999/11/24 09:00 [pubmed]
PHST- 2000/08/12 11:00 [medline]
PHST- 1999/11/24 09:00 [entrez]
AID - I307J981045 [pii]
AID - 10.3109/10425179909033929 [doi]
PST - ppublish
SO  - DNA Seq. 1999;10(1):1-6. doi: 10.3109/10425179909033929.