PMID- 10564831
OWN - NLM
STAT- MEDLINE
DCOM- 20000111
LR  - 20190707
IS  - 0378-1119 (Print)
IS  - 0378-1119 (Linking)
VI  - 240
IP  - 1
DP  - 1999 Nov 15
TI  - Human and mouse SYBL1 gene structure and expression.
PG  - 233-8
AB  - SYBL1 is a gene in the 320kb human pseudo-autosomal region at the terminus of Xq 
      and Yq. In contrast to other pseudoautosomal genes, SYBL1 is inactivated on one X
      in every female cell, and is also inactive on the Y of male cells.
      Hypermethylation of the CpG island associated with the human gene is involved in 
      this phenomenon. In an attempt to further examine its regulation, the genomic
      organization of the X-linked mouse Sybl1 homolog was analyzed and compared with
      the human gene. Human and mouse show the same exon number, exon-intron junctions 
      and a highly conserved basal promoter. The structural and functional conservation
      of basal regulatory regions suggests that inactivation is imposed by similar
      auxiliary epistatic regulatory mechanism.
FAU - Matarazzo, M R
AU  - Matarazzo MR
AD  - International Institute of Genetics and Biophysics, CNR, 80125, Naples, Italy.
FAU - Cuccurese, M
AU  - Cuccurese M
FAU - Strazzullo, M
AU  - Strazzullo M
FAU - Vacca, M
AU  - Vacca M
FAU - Curci, A
AU  - Curci A
FAU - Miano, M G
AU  - Miano MG
FAU - Cocchia, M
AU  - Cocchia M
FAU - Mercadante, G
AU  - Mercadante G
FAU - Torino, A
AU  - Torino A
FAU - D'Urso, M
AU  - D'Urso M
FAU - Ciccodicola, A
AU  - Ciccodicola A
FAU - D'Esposito, M
AU  - D'Esposito M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Gene
JT  - Gene
JID - 7706761
RN  - 0 (Membrane Proteins)
RN  - 0 (R-SNARE Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Recombinant Fusion Proteins)
RN  - 0 (Sybl1 protein, mouse)
RN  - 0 (VAMP7 protein, human)
RN  - 9007-49-2 (DNA)
RN  - EC 2.3.1.28 (Chloramphenicol O-Acetyltransferase)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - Binding Sites
MH  - Blotting, Northern
MH  - Chloramphenicol O-Acetyltransferase/genetics/metabolism
MH  - DNA/chemistry/genetics
MH  - Exons
MH  - Gene Expression
MH  - Gene Expression Regulation, Developmental
MH  - Genes/*genetics
MH  - HeLa Cells
MH  - Humans
MH  - Introns
MH  - Male
MH  - Membrane Proteins/*genetics
MH  - Mice
MH  - Molecular Sequence Data
MH  - Promoter Regions, Genetic/genetics
MH  - R-SNARE Proteins
MH  - RNA, Messenger/genetics/metabolism
MH  - Recombinant Fusion Proteins/genetics/metabolism
MH  - Regulatory Sequences, Nucleic Acid/genetics
MH  - Sequence Analysis, DNA
MH  - Sequence Homology, Nucleic Acid
MH  - Tissue Distribution
MH  - Transcription, Genetic
EDAT- 1999/11/24 00:00
MHDA- 1999/11/24 00:01
CRDT- 1999/11/24 00:00
PHST- 1999/11/24 00:00 [pubmed]
PHST- 1999/11/24 00:01 [medline]
PHST- 1999/11/24 00:00 [entrez]
AID - S0378-1119(99)00375-3 [pii]
AID - 10.1016/s0378-1119(99)00375-3 [doi]
PST - ppublish
SO  - Gene. 1999 Nov 15;240(1):233-8. doi: 10.1016/s0378-1119(99)00375-3.