PMID- 1056281
OWN - NLM
STAT- MEDLINE
DCOM- 19751010
LR  - 20191028
IS  - 0144-4107 (Print)
IS  - 0144-4107 (Linking)
VI  - 48
IP  - 6
DP  - 1975 Jun
TI  - Methionine adenosyltransferase, cystathionine beta-synthase and cystathionine
      gamma-lyase activity of rat liver subcellular particles, human blood cells and
      mixed white cells from rat bone marrow.
PG  - 509-13
AB  - 1. Methionine adenosyltransferase (ATP:L-methionine-S-adenosyl transferase, EC
      2.5.1.6), cystathionine beta-synthase F1L-serine hydro-lyase (adding
      homocysteine), EC 4.2.1.22] and cystathionine gamma-lyase [L-cystathionine
      cysteine-lyase (deaminating), EC 4.4.1.1] activities were found only in the
      cytosol fraction of rat liver cells. None was found in the mitochondrial or
      endoplasmic reticulum fractions as judged by the distribution of marker enzymes
      on a density gradient after centrifugation of the cytoplasmic fraction of a liver
      homogenate, or in a preparation of liver cell nuclei. 2. Polymorphs, lymphocytes 
      (with admixed monocytes) and mixed bone marrow white cells contained no
      methionine adenosyl transferase, cystathionine beta-synthase or cystathionine
      gamma-lyase activities. 3. The possible bearing of these results on the problem
      of abnormal cystine storage in cystinosis is briefly discussed.
FAU - Allsop, J
AU  - Allsop J
FAU - Watts, R W
AU  - Watts RW
LA  - eng
PT  - Journal Article
PL  - England
TA  - Clin Sci Mol Med Suppl
JT  - Clinical science and molecular medicine. Supplement
JID - 7907311
RN  - EC 2.- (Transferases)
RN  - EC 2.5.1.6 (Methionine Adenosyltransferase)
RN  - EC 4.- (Lyases)
RN  - EC 4.2.1.- (Hydro-Lyases)
RN  - EC 4.2.1.22 (Cystathionine beta-Synthase)
RN  - EC 4.4.1.1 (Cystathionine gamma-Lyase)
SB  - IM
MH  - Animals
MH  - Bone Marrow/*enzymology
MH  - *Bone Marrow Cells
MH  - Centrifugation, Density Gradient
MH  - Cystathionine beta-Synthase/*analysis/blood
MH  - Cystathionine gamma-Lyase/*analysis/blood
MH  - Cytosol/enzymology
MH  - Endoplasmic Reticulum/enzymology
MH  - Erythrocytes/*enzymology
MH  - Humans
MH  - Hydro-Lyases/*analysis
MH  - Leukocytes/*enzymology
MH  - Liver/*enzymology/ultrastructure
MH  - Lyases/*analysis
MH  - Male
MH  - Methionine Adenosyltransferase/*analysis/blood
MH  - Mitochondria, Liver/enzymology
MH  - Rats
MH  - Transferases/*analysis
EDAT- 1975/06/01 00:00
MHDA- 1975/06/01 00:01
CRDT- 1975/06/01 00:00
PHST- 1975/06/01 00:00 [pubmed]
PHST- 1975/06/01 00:01 [medline]
PHST- 1975/06/01 00:00 [entrez]
AID - 10.1042/cs0480509 [doi]
PST - ppublish
SO  - Clin Sci Mol Med Suppl. 1975 Jun;48(6):509-13. doi: 10.1042/cs0480509.