PMID- 10562326
OWN - NLM
STAT- MEDLINE
DCOM- 19991209
LR  - 20190508
IS  - 0022-1007 (Print)
IS  - 0022-1007 (Linking)
VI  - 190
IP  - 10
DP  - 1999 Nov 15
TI  - Clnk, a novel SLP-76-related adaptor molecule expressed in cytokine-stimulated
      hemopoietic cells.
PG  - 1527-34
AB  - We have identified a novel Src homology 2 domain-containing leukocyte protein of 
      76 kD (SLP-76)-related molecule which we have termed Clnk (for cytokine-dependent
      hemopoietic cell linker). Unlike its relatives SLP-76 and B cell linker protein
      (Blnk), Clnk is not expressed uniformly within a given hemopoietic cell lineage. 
      Even though it can be detected in several cell types, including T cells, natural 
      killer cells, and mast cells, its expression seems to be strictly dependent on
      sustained exposure to cytokines such as interleukin (IL)-2 and IL-3. Strong
      support for the notion that Clnk is involved in immunoreceptor signaling was
      provided by the observation that it inducibly associated with at least one
      tyrosine-phosphorylated polypeptide (p92) in response to immunoreceptor
      stimulation. Moreover, transient expression of Clnk caused an increase in
      immunoreceptor-mediated signaling events in a T cell line. Taken together, these 
      results show that Clnk is a novel member of the SLP-76 family selectively
      expressed in cytokine-stimulated hemopoietic cells. Furthermore, they suggest
      that Clnk may be involved in a cross-talk mechanism between cytokine receptor and
      immunoreceptor signaling.
FAU - Cao, M Y
AU  - Cao MY
AD  - McGill Cancer Centre, McGill University, Montreal, Quebec, Canada H3G 1Y6.
FAU - Davidson, D
AU  - Davidson D
FAU - Yu, J
AU  - Yu J
FAU - Latour, S
AU  - Latour S
FAU - Veillette, A
AU  - Veillette A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Exp Med
JT  - The Journal of experimental medicine
JID - 2985109R
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (B cell linker protein)
RN  - 0 (Carrier Proteins)
RN  - 0 (Cytokines)
RN  - 0 (DNA, Complementary)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (NFATC Transcription Factors)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Phosphoproteins)
RN  - 0 (Receptors, Immunologic)
RN  - 0 (SLP-76 signal Transducing adaptor proteins)
RN  - 0 (Transcription Factor AP-1)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Adaptor Proteins, Signal Transducing
MH  - Amino Acid Sequence
MH  - Animals
MH  - Carrier Proteins/physiology
MH  - Cell Line
MH  - Cytokines/*pharmacology
MH  - DNA, Complementary/analysis
MH  - DNA-Binding Proteins/metabolism
MH  - Hematopoietic System/*chemistry
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Molecular Sequence Data
MH  - NFATC Transcription Factors
MH  - *Nuclear Proteins
MH  - Phosphoproteins/genetics/*physiology
MH  - Promoter Regions, Genetic
MH  - Receptors, Immunologic/physiology
MH  - Transcription Factor AP-1/metabolism
MH  - Transcription Factors/metabolism
MH  - src Homology Domains
PMC - PMC2195705
EDAT- 1999/11/24 00:00
MHDA- 1999/11/24 00:01
CRDT- 1999/11/24 00:00
PHST- 1999/11/24 00:00 [pubmed]
PHST- 1999/11/24 00:01 [medline]
PHST- 1999/11/24 00:00 [entrez]
AID - 10.1084/jem.190.10.1527 [doi]
PST - ppublish
SO  - J Exp Med. 1999 Nov 15;190(10):1527-34. doi: 10.1084/jem.190.10.1527.