PMID- 10559964
OWN - NLM
STAT- MEDLINE
DCOM- 20000908
LR  - 20031114
IS  - 1465-7392 (Print)
IS  - 1465-7392 (Linking)
VI  - 1
IP  - 6
DP  - 1999 Oct
TI  - Selective transport of internalized antigens to the cytosol for MHC class I
      presentation in dendritic cells.
PG  - 362-8
AB  - In order for cytotoxic T cells to initiate immune responses, peptides derived
      from internalized antigens must be presented to the cytotoxic T cells on major
      histocompatibility complex (MHC) class I molecules. Here we show that dendritic
      cells, the only antigen-presenting cells that initiate immune responses
      efficiently, have developed a unique membrane transport pathway linking the lumen
      of endocytic compartments and the cytosol. Endosome-to-cytosol transport is
      restricted to dendritic cells, specific to internalized antigens and selective
      for the size of the transported molecules. Thus, in dendritic cells, internalized
      antigens gain access to the cytosolic antigen-processing machinery and to the
      conventional MHC class I antigen-presentation pathway.
FAU - Rodriguez, A
AU  - Rodriguez A
AD  - Institut National de la Sante et de la Recherche Medicale U520, Institut Curie,
      Section de Recherche, 75005 Paris, France.
FAU - Regnault, A
AU  - Regnault A
FAU - Kleijmeer, M
AU  - Kleijmeer M
FAU - Ricciardi-Castagnoli, P
AU  - Ricciardi-Castagnoli P
FAU - Amigorena, S
AU  - Amigorena S
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nat Cell Biol
JT  - Nature cell biology
JID - 100890575
RN  - 0 (Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
CIN - Nat Cell Biol. 1999 Oct;1(6):E152-4. PMID: 10559977
CIN - Nat Cell Biol. 1999 Oct;1(6):E154-5. PMID: 10559978
MH  - Animals
MH  - Antigen Presentation/*immunology
MH  - Antigens/immunology/*metabolism
MH  - Biological Transport
MH  - Cells, Cultured
MH  - Cytosol/immunology
MH  - Dendritic Cells/cytology/*immunology
MH  - Endocytosis/*immunology
MH  - Histocompatibility Antigens Class I/*immunology
MH  - Macrophages/immunology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Ovalbumin/immunology
EDAT- 1999/11/24 09:00
MHDA- 2000/09/19 11:01
CRDT- 1999/11/24 09:00
PHST- 1999/11/24 09:00 [pubmed]
PHST- 2000/09/19 11:01 [medline]
PHST- 1999/11/24 09:00 [entrez]
AID - 10.1038/14058 [doi]
PST - ppublish
SO  - Nat Cell Biol. 1999 Oct;1(6):362-8. doi: 10.1038/14058.