PMID- 10559940
OWN - NLM
STAT- MEDLINE
DCOM- 19991206
LR  - 20170922
IS  - 1465-7392 (Print)
IS  - 1465-7392 (Linking)
VI  - 1
IP  - 5
DP  - 1999 Sep
TI  - ARF mediates recruitment of PtdIns-4-OH kinase-beta and stimulates synthesis of
      PtdIns(4,5)P2 on the Golgi complex.
PG  - 280-7
AB  - The small GTPase ADP-ribosylation factor (ARF) regulates the structure and
      function of the Golgi complex through mechanisms that are understood only in
      part, and which include an ability to control the assembly of coat complexes and 
      phospholipase D (PLD). Here we describe a new property of ARF, the ability to
      recruit phosphatidylinositol-4-OH kinase-beta and a still unidentified
      phosphatidylinositol-4-phosphate-5-OH kinase to the Golgi complex, resulting in a
      potent stimulation of synthesis of phosphatidylinositol-4-phosphate and
      phosphatidylinositol-4,5-bisphosphate; this ability is independent of its
      activities on coat proteins and PLD. Phosphatidylinositol-4-OH kinase-beta is
      required for the structural integrity of the Golgi complex: transfection of a
      dominant-negative mutant of the kinase markedly alters the organization of the
      organelle.
FAU - Godi, A
AU  - Godi A
AD  - Department of Cell Biology and Oncology, Istituto di Ricerche Farmacologiche
      Mario Negri, Santa Maria Imbaro, Italy.
FAU - Pertile, P
AU  - Pertile P
FAU - Meyers, R
AU  - Meyers R
FAU - Marra, P
AU  - Marra P
FAU - Di Tullio, G
AU  - Di Tullio G
FAU - Iurisci, C
AU  - Iurisci C
FAU - Luini, A
AU  - Luini A
FAU - Corda, D
AU  - Corda D
FAU - De Matteis, M A
AU  - De Matteis MA
LA  - eng
GR  - E.0732/Telethon/Italy
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Nat Cell Biol
JT  - Nature cell biology
JID - 100890575
RN  - 0 (Membrane Lipids)
RN  - 0 (Phosphatidylinositol 4,5-Diphosphate)
RN  - EC 2.7.1.67 (1-Phosphatidylinositol 4-Kinase)
RN  - EC 3.1.4.4 (Phospholipase D)
RN  - EC 3.6.5.2 (ADP-Ribosylation Factors)
SB  - IM
CIN - Nat Cell Biol. 1999 Sep;1(5):E113-5. PMID: 10559947
MH  - 1-Phosphatidylinositol 4-Kinase/*metabolism
MH  - ADP-Ribosylation Factors/*metabolism
MH  - Animals
MH  - Brain/metabolism
MH  - Cattle
MH  - Cell Line
MH  - Cytosol/metabolism
MH  - Golgi Apparatus/*metabolism
MH  - Intracellular Membranes/metabolism
MH  - Liver/metabolism
MH  - Membrane Lipids/*biosynthesis
MH  - Phosphatidylinositol 4,5-Diphosphate/*biosynthesis
MH  - Phospholipase D/metabolism
MH  - Rats
EDAT- 1999/11/13 09:00
MHDA- 2001/03/23 10:01
CRDT- 1999/11/13 09:00
PHST- 1999/11/13 09:00 [pubmed]
PHST- 2001/03/23 10:01 [medline]
PHST- 1999/11/13 09:00 [entrez]
AID - 10.1038/12993 [doi]
PST - ppublish
SO  - Nat Cell Biol. 1999 Sep;1(5):280-7. doi: 10.1038/12993.