PMID- 10559903
OWN - NLM
STAT- MEDLINE
DCOM- 19991216
LR  - 20181130
IS  - 1465-7392 (Print)
IS  - 1465-7392 (Linking)
VI  - 1
IP  - 3
DP  - 1999 Jul
TI  - Translocation of a calcium-permeable cation channel induced by insulin-like
      growth factor-I.
PG  - 165-70
AB  - Calcium plays a critical part in the regulation of cell growth, and growth
      factors stimulate calcium entry into cells through calcium-permeable channels.
      However, the molecular nature and regulation of calcium-permeable channels are
      still unclear at present. Here we report the molecular characterization of a
      calcium-permeable cation channel that is regulated by insulin-like growth
      factor-I (IGF-I). This channel, which we name growth-factor-regulated channel
      (GRC), belongs to the TRP-channel family and localizes mainly to intracellular
      pools under basal conditions. Upon stimulation of cells by IGF-I, GRC
      translocates to the plasma membrane. Thus, IGF-I augments calcium entry through
      GRC by regulating trafficking of the channel.
FAU - Kanzaki, M
AU  - Kanzaki M
AD  - Department of Cell Biology, Gunma University, Maebashi, Japan.
FAU - Zhang, Y Q
AU  - Zhang YQ
FAU - Mashima, H
AU  - Mashima H
FAU - Li, L
AU  - Li L
FAU - Shibata, H
AU  - Shibata H
FAU - Kojima, I
AU  - Kojima I
LA  - eng
SI  - GENBANK/AB021665
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Nat Cell Biol
JT  - Nature cell biology
JID - 100890575
RN  - 0 (Androstadienes)
RN  - 0 (Calcium Channels)
RN  - 0 (Chromones)
RN  - 0 (Morpholines)
RN  - 0 (Recombinant Fusion Proteins)
RN  - 0 (TRPV Cation Channels)
RN  - 0 (TRPV2 protein, human)
RN  - 0 (Trpv2 protein, mouse)
RN  - 31M2U1DVID (2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
RN  - EC 2.7.1.- (Phosphatidylinositol 3-Kinases)
RN  - SY7Q814VUP (Calcium)
RN  - XVA4O219QW (Wortmannin)
SB  - IM
MH  - 3T3 Cells
MH  - Amino Acid Sequence
MH  - Androstadienes/pharmacology
MH  - Animals
MH  - Calcium/*metabolism
MH  - Calcium Channels/chemistry/genetics/*physiology
MH  - Cattle
MH  - Cell Membrane/*physiology
MH  - Chromones/pharmacology
MH  - Cloning, Molecular
MH  - Cytosol/metabolism
MH  - Gene Expression Regulation/drug effects/*physiology
MH  - Humans
MH  - Insulin-Like Growth Factor I/*pharmacology/physiology
MH  - Membrane Potentials/drug effects
MH  - Mice
MH  - Molecular Sequence Data
MH  - Morpholines/pharmacology
MH  - Phosphatidylinositol 3-Kinases/metabolism
MH  - Phylogeny
MH  - Rats
MH  - Recombinant Fusion Proteins/biosynthesis/chemistry
MH  - Sequence Alignment
MH  - Sequence Homology, Amino Acid
MH  - TRPV Cation Channels
MH  - Transfection
MH  - Wortmannin
EDAT- 1999/11/13 09:00
MHDA- 2001/03/23 10:01
CRDT- 1999/11/13 09:00
PHST- 1999/11/13 09:00 [pubmed]
PHST- 2001/03/23 10:01 [medline]
PHST- 1999/11/13 09:00 [entrez]
AID - 10.1038/11086 [doi]
PST - ppublish
SO  - Nat Cell Biol. 1999 Jul;1(3):165-70. doi: 10.1038/11086.