PMID- 10559501
OWN - NLM
STAT- MEDLINE
DCOM- 20000204
LR  - 20190910
IS  - 0925-4773 (Print)
IS  - 0925-4773 (Linking)
VI  - 89
IP  - 1-2
DP  - 1999 Dec
TI  - Whn and mHa3 are components of the genetic hierarchy controlling hair follicle
      differentiation.
PG  - 215-21
AB  - The molecular basis of the characteristic hair growth disorder in nude mice that 
      carry a defective Whn transcription factor gene is unknown. A comparison of mRNA 
      populations from wild-type and nude mice back skin by representational difference
      analysis revealed the absence of acidic hair keratin gene 3 (mHa3) mRNA in mutant
      mice. Whn and acidic hair keratin genes are co-expressed in hair follicles, nail 
      forming regions and filiform papillae of the tongue: expression of the mHa3 gene 
      is generally detectable about 1 day after Whn mRNA and rapidly ceases in its
      absence. Whn is strongly expressed during the anagen (growth) phase of the hair
      cycle in matrix, cortex and outer root sheath; its expression rapidly declines
      during catagen and is undetectable in telogen phases. In nude mice, low levels of
      mHa3 expression are maintained in nails and whisker follicles, whereas expression
      is completely absent in pelage hair follicles and filiform papillae. Thus, the
      nude phenotype represents the first example of an inherited skin disorder that is
      associated with the loss of expression rather than structural mutation of keratin
      genes. The distinct molecular difference between pelage and whisker follicles
      correlates with the improved mechanical stability of vibrissae in nude mice,
      implicating mHa3 as an important structural component of the hair shaft.
FAU - Meier, N
AU  - Meier N
AD  - Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D-69120, Heidelberg,
      Germany.
FAU - Dear, T N
AU  - Dear TN
FAU - Boehm, T
AU  - Boehm T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Mech Dev
JT  - Mechanisms of development
JID - 9101218
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Forkhead Transcription Factors)
RN  - 0 (Keratins, Hair-Specific)
RN  - 0 (Keratins, Type I)
RN  - 0 (Krt32 protein, mouse)
RN  - 0 (Transcription Factors)
RN  - 0 (Whn protein)
RN  - 68238-35-7 (Keratins)
SB  - IM
MH  - Animals
MH  - Cell Differentiation/*genetics
MH  - DNA-Binding Proteins/*genetics/metabolism
MH  - Forkhead Transcription Factors
MH  - Gene Expression Profiling
MH  - Gene Expression Regulation, Developmental
MH  - Hair Follicle/*physiology
MH  - Keratins/*genetics/metabolism
MH  - Keratins, Hair-Specific
MH  - Keratins, Type I
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Mice, Mutant Strains
MH  - Mice, Nude
MH  - Thymus Gland/embryology
MH  - Transcription Factors/*genetics/metabolism
EDAT- 1999/11/24 00:00
MHDA- 1999/11/24 00:01
CRDT- 1999/11/24 00:00
PHST- 1999/11/24 00:00 [pubmed]
PHST- 1999/11/24 00:01 [medline]
PHST- 1999/11/24 00:00 [entrez]
AID - S0925-4773(99)00218-X [pii]
AID - 10.1016/s0925-4773(99)00218-x [doi]
PST - ppublish
SO  - Mech Dev. 1999 Dec;89(1-2):215-21. doi: 10.1016/s0925-4773(99)00218-x.