PMID- 10559471
OWN - NLM
STAT- MEDLINE
DCOM- 19991228
LR  - 20190610
IS  - 0006-3002 (Print)
IS  - 0006-3002 (Linking)
VI  - 1452
IP  - 2
DP  - 1999 Nov 11
TI  - Non-adherent cell-specific expression of DOCK2, a member of the human CDM-family 
      proteins.
PG  - 179-87
AB  - Human DOCK180, which was originally identified as a major protein bound to the
      Crk oncogene product, is an archetype of the CDM family of proteins, including
      Ced-5 of Caenorhabditis elegans and Mbc of Drosophila melanogaster. After
      DOCK180, at least three putative human proteins that manifest high amino acid
      sequence similarity to DOCK180 have been registered in the GenBank/EMBL database.
      We have designated one of them, KIAA0209, as DOCK2 and characterize here. DOCK2
      mRNA was expressed mostly in peripheral blood cells, followed by slight
      expression in the spleen and thymus, whereas DOCK180 was expressed in all tissues
      tested except in peripheral blood cells. Immunostaining of human cadaver tissues 
      revealed that the expression of DOCK2 was limited to the lymphocytes and
      macrophages of various organs. DOCK2 bound to and activated Rac1, as did DOCK180;
      however, DOCK2 did not bind to CrkII, which transduces signals at focal
      adhesions. Thus, DOCK180 and DOCK2 are regulators of Rac and function in adherent
      and non-adherent cells, respectively.
FAU - Nishihara, H
AU  - Nishihara H
AD  - Department of Pathology, Research Institute, International Medical Center of
      Japan, 1-21-1 Toyama, Shinjuku-ku, Tokyo, Japan.
FAU - Kobayashi, S
AU  - Kobayashi S
FAU - Hashimoto, Y
AU  - Hashimoto Y
FAU - Ohba, F
AU  - Ohba F
FAU - Mochizuki, N
AU  - Mochizuki N
FAU - Kurata, T
AU  - Kurata T
FAU - Nagashima, K
AU  - Nagashima K
FAU - Matsuda, M
AU  - Matsuda M
LA  - eng
SI  - GENBANK/D86964
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Biochim Biophys Acta
JT  - Biochimica et biophysica acta
JID - 0217513
RN  - 0 (BCAP31 protein, human)
RN  - 0 (CED-5 protein, C elegans)
RN  - 0 (Caenorhabditis elegans Proteins)
RN  - 0 (Carrier Proteins)
RN  - 0 (DNA, Complementary)
RN  - 0 (DOCK1 protein, human)
RN  - 0 (DOCK2 protein, human)
RN  - 0 (Guanine Nucleotide Exchange Factors)
RN  - 0 (Membrane Proteins)
RN  - 0 (Proteins)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Proto-Oncogene Proteins c-crk)
RN  - 0 (RNA, Messenger)
RN  - EC 2.7.- (Protein Kinases)
RN  - EC 3.6.1.- (rac2 GTP-binding protein)
RN  - EC 3.6.5.2 (rac GTP-Binding Proteins)
RN  - EC 3.6.5.2 (rac1 GTP-Binding Protein)
SB  - IM
MH  - Amino Acid Sequence
MH  - *Caenorhabditis elegans Proteins
MH  - Carrier Proteins/chemistry/isolation & purification/*metabolism
MH  - DNA, Complementary/chemistry
MH  - *Guanine Nucleotide Exchange Factors
MH  - Humans
MH  - Immunohistochemistry
MH  - Leukocytes/metabolism
MH  - Membrane Proteins/chemistry
MH  - Molecular Sequence Data
MH  - Protein Kinases/metabolism
MH  - Proteins/chemistry/*metabolism
MH  - *Proto-Oncogene Proteins
MH  - Proto-Oncogene Proteins c-crk
MH  - RNA, Messenger/analysis/metabolism
MH  - Sequence Homology, Amino Acid
MH  - Spleen/metabolism
MH  - Thymus Gland/metabolism
MH  - rac GTP-Binding Proteins/metabolism
MH  - rac1 GTP-Binding Protein/metabolism
EDAT- 1999/11/24 00:00
MHDA- 1999/11/24 00:01
CRDT- 1999/11/24 00:00
PHST- 1999/11/24 00:00 [pubmed]
PHST- 1999/11/24 00:01 [medline]
PHST- 1999/11/24 00:00 [entrez]
AID - S0167-4889(99)00133-0 [pii]
AID - 10.1016/s0167-4889(99)00133-0 [doi]
PST - ppublish
SO  - Biochim Biophys Acta. 1999 Nov 11;1452(2):179-87. doi:
      10.1016/s0167-4889(99)00133-0.