PMID- 10557333
OWN - NLM
STAT- MEDLINE
DCOM- 19991213
LR  - 20190501
IS  - 0027-8424 (Print)
IS  - 0027-8424 (Linking)
VI  - 96
IP  - 23
DP  - 1999 Nov 9
TI  - An ancient family of human endogenous retroviruses encodes a functional homolog
      of the HIV-1 Rev protein.
PG  - 13404-8
AB  - The human endogenous retrovirus K (HERV-K) family of endogenous retroviruses
      consists of approximately 50 proviral copies per haploid human genome. Herein,
      the HERV-Ks are shown to encode a sequence-specific nuclear RNA export factor,
      termed K-Rev, that is functionally analogous to the HIV-1 Rev protein. Like HIV-1
      Rev, K-Rev binds to both the Crm1 nuclear export factor and to a cis-acting viral
      RNA target to activate nuclear export of unspliced RNAs. Surprisingly, this
      HERV-K RNA sequence, which is encoded within the HERV-K long terminal repeat, is 
      also recognized by HIV-1 Rev. These data provide surprising evidence for an
      evolutionary link between HIV-1 and a group of endogenous retroviruses that first
      entered the human genome approximately 30 million years ago.
FAU - Yang, J
AU  - Yang J
AD  - Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC
      27710, USA.
FAU - Bogerd, H P
AU  - Bogerd HP
FAU - Peng, S
AU  - Peng S
FAU - Wiegand, H
AU  - Wiegand H
FAU - Truant, R
AU  - Truant R
FAU - Cullen, B R
AU  - Cullen BR
LA  - eng
SI  - GENBANK/AF179225
PT  - Journal Article
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (Carrier Proteins)
RN  - 0 (Gene Products, rev)
RN  - 0 (Karyopherins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (RNA-Binding Proteins)
RN  - 0 (Receptors, Cytoplasmic and Nuclear)
RN  - 0 (exportin 1 protein)
RN  - 0 (rev Gene Products, Human Immunodeficiency Virus)
SB  - IM
SB  - X
MH  - Carrier Proteins/metabolism
MH  - Cell Line
MH  - Cell Nucleus/metabolism
MH  - Cloning, Molecular
MH  - Gene Products, rev/*genetics/metabolism
MH  - HIV-1/*genetics
MH  - Humans
MH  - *Karyopherins
MH  - Molecular Sequence Data
MH  - Nuclear Proteins/metabolism
MH  - Protein Binding
MH  - RNA-Binding Proteins/metabolism
MH  - *Receptors, Cytoplasmic and Nuclear
MH  - Retroviridae/*genetics
MH  - rev Gene Products, Human Immunodeficiency Virus
PMC - PMC23960
EDAT- 1999/11/11 00:00
MHDA- 1999/11/11 00:01
CRDT- 1999/11/11 00:00
PHST- 1999/11/11 00:00 [pubmed]
PHST- 1999/11/11 00:01 [medline]
PHST- 1999/11/11 00:00 [entrez]
AID - 10.1073/pnas.96.23.13404 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 1999 Nov 9;96(23):13404-8. doi:
      10.1073/pnas.96.23.13404.