PMID- 10557207
OWN - NLM
STAT- MEDLINE
DCOM- 19991222
LR  - 20190516
IS  - 0890-9369 (Print)
IS  - 0890-9369 (Linking)
VI  - 13
IP  - 21
DP  - 1999 Nov 1
TI  - Progressive impairment of developing neuroendocrine cell lineages in the
      hypothalamus of mice lacking the Orthopedia gene.
PG  - 2787-800
AB  - Development of the neuroendocrine hypothalamus is characterized by a precise
      series of morphogenetic milestones culminating in terminal differentiation of
      neurosecretory cell lineages. The homeobox-containing gene Orthopedia (Otp) is
      expressed in neurons giving rise to the paraventricular (PVN), supraoptic (SON), 
      anterior periventricular (aPV), and arcuate (ARN) nuclei throughout their
      development. Homozygous Otp(-/-) mice die soon after birth and display
      progressive impairment of crucial neuroendocrine developmental events such as
      reduced cell proliferation, abnormal cell migration, and failure in terminal
      differentiation of the parvocellular and magnocellular neurons of the aPV, PVN,
      SON, and ARN. Moreover, our data provide evidence that Otp and Sim1, a bHLH-PAS
      transcription factor that directs terminal differentiation of the PVN, SON, and
      aPV, act in parallel and are both required to maintain Brn2 expression which, in 
      turn, is required for neuronal cell lineages secreting oxytocin (OT), arginine
      vasopressin (AVP), and corticotropin-releasing hormone (CRH).
FAU - Acampora, D
AU  - Acampora D
AD  - International Institute of Genetics and Biophysics, Consiglio Nationale delle
      Ricerche (CNR), 80125 Naples, Italy.
FAU - Postiglione, M P
AU  - Postiglione MP
FAU - Avantaggiato, V
AU  - Avantaggiato V
FAU - Di Bonito, M
AU  - Di Bonito M
FAU - Vaccarino, F M
AU  - Vaccarino FM
FAU - Michaud, J
AU  - Michaud J
FAU - Simeone, A
AU  - Simeone A
LA  - eng
GR  - D.037/Telethon/Italy
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Genes Dev
JT  - Genes & development
JID - 8711660
RN  - 0 (Homeodomain Proteins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (OTP protein, human)
RN  - 0 (Otp protein, mouse)
SB  - IM
MH  - Animals
MH  - Apoptosis
MH  - Body Patterning
MH  - Cell Division
MH  - Cell Lineage/*genetics
MH  - Female
MH  - Gene Deletion
MH  - HeLa Cells
MH  - Homeodomain Proteins/genetics/*physiology
MH  - Humans
MH  - Hypothalamus/cytology/*embryology
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Mutant Strains
MH  - Nerve Tissue Proteins/genetics/*physiology
PMC - PMC317121
EDAT- 1999/11/11 00:00
MHDA- 1999/11/11 00:01
CRDT- 1999/11/11 00:00
PHST- 1999/11/11 00:00 [pubmed]
PHST- 1999/11/11 00:01 [medline]
PHST- 1999/11/11 00:00 [entrez]
AID - 10.1101/gad.13.21.2787 [doi]
PST - ppublish
SO  - Genes Dev. 1999 Nov 1;13(21):2787-800. doi: 10.1101/gad.13.21.2787.