PMID- 10557087
OWN - NLM
STAT- MEDLINE
DCOM- 19991203
LR  - 20120625
IS  - 0950-9232 (Print)
IS  - 0950-9232 (Linking)
VI  - 18
IP  - 44
DP  - 1999 Oct 28
TI  - Overexpression of Frat1 in transgenic mice leads to glomerulosclerosis and
      nephrotic syndrome, and provides direct evidence for the involvement of Frat1 in 
      lymphoma progression.
PG  - 5982-90
AB  - The proto-oncogene Frat1 was originally identified as a common site of proviral
      insertion in transplanted tumors of Moloney murine leukemia virus
      (M-MuLV)-infected Emu-Pim1 transgenic mice. Contrary to most common insertion
      sites implicated in mouse T cell lymphomagenesis, retroviral insertional
      mutagenesis of Frat1 constitutes a relatively late event in M-MuLV-induced tumor 
      development, suggesting that proviral activation of Frat1 contributes to
      progression of T cell lymphomas rather than their genesis. To substantiate this
      notion we have generated transgenic mice that overexpress Frat1 in various
      organs, including lymphoid tissues. Frat1 transgenic mice develop focal
      glomerulosclerosis and a nephrotic syndrome, but they do not exhibit an increased
      incidence of spontaneous lymphomas. Conversely, these mice are highly susceptible
      to M-MuLV-induced lymphomagenesis, and Frat1/Pim1 bitransgenic animals develop
      lymphomas with increased frequency compared to Pim1 transgenic littermates. These
      data support a role for Frat1 in tumor progression.
FAU - Jonkers, J
AU  - Jonkers J
AD  - Division of Molecular Genetics and Center of Biomedical Genetics, The Netherlands
      Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.
FAU - Weening, J J
AU  - Weening JJ
FAU - van der Valk, M
AU  - van der Valk M
FAU - Bobeldijk, R
AU  - Bobeldijk R
FAU - Berns, A
AU  - Berns A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Oncogene
JT  - Oncogene
JID - 8711562
RN  - 0 (Carrier Proteins)
RN  - 0 (Frat1 protein, mouse)
RN  - 0 (Immunoglobulin Heavy Chains)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Proto-Oncogene Proteins)
RN  - EC 2.7.11.1 (Pim1 protein, mouse)
RN  - EC 2.7.11.1 (Protein-Serine-Threonine Kinases)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-pim-1)
SB  - IM
MH  - Animals
MH  - Bone Marrow Transplantation
MH  - *Carrier Proteins
MH  - Disease Progression
MH  - Enhancer Elements, Genetic
MH  - Female
MH  - Gene Expression Regulation
MH  - Genetic Predisposition to Disease
MH  - Glomerulosclerosis, Focal Segmental/*genetics/pathology
MH  - Immunoglobulin Heavy Chains/genetics
MH  - Lymphoma/*genetics/virology
MH  - Male
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Mice, Transgenic
MH  - Moloney murine leukemia virus/pathogenicity
MH  - *Neoplasm Proteins
MH  - Nephrotic Syndrome/*genetics
MH  - Protein-Serine-Threonine Kinases
MH  - Proto-Oncogene Proteins/*genetics/metabolism
MH  - Proto-Oncogene Proteins c-pim-1
EDAT- 1999/11/11 00:00
MHDA- 1999/11/11 00:01
CRDT- 1999/11/11 00:00
PHST- 1999/11/11 00:00 [pubmed]
PHST- 1999/11/11 00:01 [medline]
PHST- 1999/11/11 00:00 [entrez]
AID - 10.1038/sj.onc.1202995 [doi]
PST - ppublish
SO  - Oncogene. 1999 Oct 28;18(44):5982-90. doi: 10.1038/sj.onc.1202995.