PMID- 10557084
OWN - NLM
STAT- MEDLINE
DCOM- 19991203
LR  - 20161124
IS  - 0950-9232 (Print)
IS  - 0950-9232 (Linking)
VI  - 18
IP  - 44
DP  - 1999 Oct 28
TI  - Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent
      transcriptional response.
PG  - 5959-66
AB  - The human homologue of fz1 (Hfz1) was cloned from a cDNA library. Hfz1 was shown 
      to couple to Wnt signal transduction pathways by its ability to enhance Wnt
      induced TCF dependent transcription in both autocrine and paracrine modes.
      Enhanced TCF dependent signaling was dose dependent with respect to both Wnt-3A
      and Hfz1. Moreover, Hfz1 deletion mutants with truncated carboxy termini showed
      markedly reduced capacity to enhance Wnt signal transduction. Specificity was
      demonstrated with respect to signal transduction by different Wnts. While Wnt-3a,
      -3, -1 and to a lesser extent Wnt-2 cooperated with Hfz1 in the paracrine assay
      for TCF dependent signaling, neither Wnt-4, -5a, -5b, -6, -7a nor -7b did so,
      despite similar levels of expression. However, coimmunoprecipitation of Hfz1 with
      both Wnt-3a and Wnt-5a indicated that TCF dependent signaling in response to Wnts
      is not determined solely by their ability to bind the receptor. All of these
      findings provide strong evidence that Hfz1 is a functional partner for certain
      Wnts in inducing TCF dependent transcription.
FAU - Gazit, A
AU  - Gazit A
AD  - Department of Human Microbiology, Sackler School of Medicine, Tel-Aviv
      University, Tel-Aviv 69978, Israel.
FAU - Yaniv, A
AU  - Yaniv A
FAU - Bafico, A
AU  - Bafico A
FAU - Pramila, T
AU  - Pramila T
FAU - Igarashi, M
AU  - Igarashi M
FAU - Kitajewski, J
AU  - Kitajewski J
FAU - Aaronson, S A
AU  - Aaronson SA
LA  - eng
SI  - GENBANK/AF054623
GR  - R01-CA71672/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Oncogene
JT  - Oncogene
JID - 8711562
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (FZD1 protein, human)
RN  - 0 (Frizzled Receptors)
RN  - 0 (Fzd1 protein, mouse)
RN  - 0 (Lymphoid Enhancer-Binding Factor 1)
RN  - 0 (Proteins)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Receptors, G-Protein-Coupled)
RN  - 0 (Receptors, Neurotransmitter)
RN  - 0 (Transcription Factors)
RN  - 0 (WNT2 protein, human)
RN  - 0 (WNT3A protein, human)
RN  - 0 (WNT4 protein, human)
RN  - 0 (WNT5A protein, human)
RN  - 0 (WNT6 protein, human)
RN  - 0 (WNT7A protein, human)
RN  - 0 (Wnt Proteins)
RN  - 0 (Wnt-5a Protein)
RN  - 0 (Wnt2 Protein)
RN  - 0 (Wnt3 Protein)
RN  - 0 (Wnt3A Protein)
RN  - 0 (Wnt3a protein, mouse)
RN  - 0 (Wnt4 Protein)
RN  - 0 (Wnt4 protein, mouse)
RN  - 0 (Wnt4 protein, rat)
RN  - 0 (Wnt7a protein, mouse)
RN  - 0 (Wnt7a protein, rat)
RN  - 0 (Zebrafish Proteins)
SB  - IM
MH  - Cell Line
MH  - Cell Transformation, Neoplastic
MH  - Cloning, Molecular
MH  - DNA-Binding Proteins/genetics/*metabolism
MH  - Frizzled Receptors
MH  - Humans
MH  - Lymphoid Enhancer-Binding Factor 1
MH  - Molecular Biology/methods
MH  - Molecular Sequence Data
MH  - Mutation
MH  - Proteins/genetics/*metabolism
MH  - Proto-Oncogene Proteins/genetics/metabolism
MH  - Receptors, G-Protein-Coupled
MH  - Receptors, Neurotransmitter/*genetics/*metabolism
MH  - Sensitivity and Specificity
MH  - Sequence Analysis
MH  - Signal Transduction
MH  - Transcription Factors/genetics/*metabolism
MH  - Transcription, Genetic
MH  - Transfection
MH  - Wnt Proteins
MH  - Wnt-5a Protein
MH  - Wnt2 Protein
MH  - Wnt3 Protein
MH  - Wnt3A Protein
MH  - Wnt4 Protein
MH  - *Zebrafish Proteins
EDAT- 1999/11/11 00:00
MHDA- 1999/11/11 00:01
CRDT- 1999/11/11 00:00
PHST- 1999/11/11 00:00 [pubmed]
PHST- 1999/11/11 00:01 [medline]
PHST- 1999/11/11 00:00 [entrez]
AID - 10.1038/sj.onc.1202985 [doi]
PST - ppublish
SO  - Oncogene. 1999 Oct 28;18(44):5959-66. doi: 10.1038/sj.onc.1202985.