PMID- 10557083
OWN - NLM
STAT- MEDLINE
DCOM- 19991210
LR  - 20071114
IS  - 0950-9232 (Print)
IS  - 0950-9232 (Linking)
VI  - 18
IP  - 43
DP  - 1999 Oct 21
TI  - Down-regulation of the stathmin/Op18 and FKBP25 genes following p53 induction.
PG  - 5954-8
AB  - The p53 tumor suppressor protein can function as an activator and a repressor of 
      gene transcription. Currently, the mechanism of transcriptional repression by p53
      is poorly understood. To aid in clarifying this mechanism, we carried out studies
      designed to identify specific target genes that are down-regulated following p53 
      induction. Among the negative p53-response genes revealed by our screening
      protocols are those encoding stathmin (Op18), a tubulin-associated protein
      implicated in cell signaling pathways, and an FK506/rapamycin-binding protein,
      FKBP25. Stathmin and FKBP25 exhibit decreased expression in both human and murine
      immortalized and transformed cell lines following induction of wild-type p53 by
      several stimuli that result in DNA damage. Candidate p53-repressed genes such as 
      these provide the necessary markers to delineate the mechanism and biological
      consequences of transcriptional repression mediated by p53.
FAU - Ahn, J
AU  - Ahn J
AD  - Department of Genetics, University of Pennsylvania School of Medicine,
      Philadelphia, Pennyslvania, PA 19104-6069, USA.
FAU - Murphy, M
AU  - Murphy M
FAU - Kratowicz, S
AU  - Kratowicz S
FAU - Wang, A
AU  - Wang A
FAU - Levine, A J
AU  - Levine AJ
FAU - George, D L
AU  - George DL
LA  - eng
GR  - CA41086/CA/NCI NIH HHS/United States
GR  - CA466741/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Oncogene
JT  - Oncogene
JID - 8711562
RN  - 0 (Fkbp3 protein, mouse)
RN  - 0 (Microtubule Proteins)
RN  - 0 (Phosphoproteins)
RN  - 0 (STMN1 protein, human)
RN  - 0 (Stathmin)
RN  - 0 (Stmn1 protein, mouse)
RN  - 0 (Tumor Suppressor Protein p53)
RN  - 147478-69-1 (FKBP3 protein, human)
RN  - EC 5.2.1.- (Tacrolimus Binding Proteins)
RN  - EC 5.2.1.8 (Immunophilins)
SB  - IM
MH  - Animals
MH  - Cell Line
MH  - *Down-Regulation
MH  - Humans
MH  - Immunophilins/*genetics
MH  - Mice
MH  - *Microtubule Proteins
MH  - Phosphoproteins/*genetics
MH  - Stathmin
MH  - *Tacrolimus Binding Proteins
MH  - Tumor Cells, Cultured
MH  - Tumor Suppressor Protein p53/*metabolism
EDAT- 1999/11/11 00:00
MHDA- 1999/11/11 00:01
CRDT- 1999/11/11 00:00
PHST- 1999/11/11 00:00 [pubmed]
PHST- 1999/11/11 00:01 [medline]
PHST- 1999/11/11 00:00 [entrez]
AID - 10.1038/sj.onc.1202986 [doi]
PST - ppublish
SO  - Oncogene. 1999 Oct 21;18(43):5954-8. doi: 10.1038/sj.onc.1202986.