PMID- 10556784
OWN - NLM
STAT- MEDLINE
DCOM- 19991223
LR  - 20190709
IS  - 0022-0795 (Print)
IS  - 0022-0795 (Linking)
VI  - 163
IP  - 2
DP  - 1999 Nov
TI  - C-Jun phosphorylation (Ser-63) in the testis of the lizard, Podarcis s. sicula.
PG  - 337-44
AB  - Proto-oncogenes play an important role in the regulation of cellular growth and
      differentiation. C-Jun activity has been studied in the testis of a non mammalian
      vertebrate, the lizard Podarcis s. sicula, during two different periods: winter
      stasis and the breeding season. C-Jun protein was localized by
      immunocytochemistry in the cytoplasm of the spermatogonia (SPG) and stage I and
      II spermatocytes (SPC) during the winter stasis (from December until March),
      while the protein was present in the nuclei of the same cells during the active
      spermatogenic period (April/May). The different localization of c-Jun has been
      confirmed by Western blot and immunoprecipitation analysis. In addition, when Jun
      is present in the nuclear compartment, it is phosphorylated on Ser-63 and is
      complexed with Fos protein. These data suggest that the nuclear localization of
      the Jun protein in the SPG and stage I and II SPC, with strong phosphorylation on
      Ser-63 during the breeding period, could be the signal of increasing
      transcriptional activity in the lizard testis.
FAU - Chieffi, P
AU  - Chieffi P
AD  - Dipartimento di Biologia e Patologia Cellulare e Molecolare 'L Califano',
      Universita di Napoli 'Federico II', Naples, Italy. chieffi@unina.it
FAU - Picascia, A
AU  - Picascia A
FAU - Stanzione, R
AU  - Stanzione R
FAU - Tramontano, D
AU  - Tramontano D
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Endocrinol
JT  - The Journal of endocrinology
JID - 0375363
RN  - 0 (Proto-Oncogene Proteins c-fos)
RN  - 0 (Proto-Oncogene Proteins c-jun)
SB  - IM
MH  - Animals
MH  - Blotting, Western
MH  - Immunoenzyme Techniques
MH  - Lizards/*metabolism
MH  - Male
MH  - Phosphorylation
MH  - Proto-Oncogene Proteins c-fos/metabolism
MH  - Proto-Oncogene Proteins c-jun/*metabolism
MH  - Seasons
MH  - Spermatogenesis/physiology
MH  - Spermatogonia/metabolism
MH  - Spermatozoa/metabolism
MH  - Testis/*metabolism
EDAT- 1999/11/11 00:00
MHDA- 1999/11/11 00:01
CRDT- 1999/11/11 00:00
PHST- 1999/11/11 00:00 [pubmed]
PHST- 1999/11/11 00:01 [medline]
PHST- 1999/11/11 00:00 [entrez]
AID - JOE03454 [pii]
AID - 10.1677/joe.0.1630337 [doi]
PST - ppublish
SO  - J Endocrinol. 1999 Nov;163(2):337-44. doi: 10.1677/joe.0.1630337.