PMID- 10556508
OWN - NLM
STAT- MEDLINE
DCOM- 19991222
LR  - 20190621
IS  - 0014-5793 (Print)
IS  - 0014-5793 (Linking)
VI  - 460
IP  - 3
DP  - 1999 Nov 5
TI  - Alternative splicing of synaptotagmins involving transmembrane exon skipping.
PG  - 417-22
AB  - The synaptotagmin gene family currently includes 12 members. Analysis of the
      three known genomic synaptotagmin sequences reveals conserved exon-intron
      patterns which delineate the synaptotagmin structural domains. We used expressed 
      sequence tag, reverse transcription PCR and RNAse protection assay analysis of
      synaptotagmin messenger RNAs to demonstrate the occurrence of alternative
      splicing events involving a number of exons. Exon-skipped messages where
      transmembrane sequences have been removed or altered were found to be abundantly 
      expressed by synaptotagmins 1, 4, 6 and 7. Although the expression of most
      synaptotagmins predominates in neural tissue, we find that by contrast,
      synaptotagmin 6 is more abundant in thymus.
FAU - Craxton, M
AU  - Craxton M
AD  - Medical Research Council, Laboratory of Molecular Biology, Hills Road, Cambridge,
      UK. molly@mrc-lmb.cam.ac.uk
FAU - Goedert, M
AU  - Goedert M
LA  - eng
SI  - GENBANK/AC006409
SI  - GENBANK/Y19236
SI  - GENBANK/Y19237
SI  - GENBANK/Y19238
SI  - GENBANK/Y19239
SI  - GENBANK/Y19240
SI  - GENBANK/Y19241
SI  - GENBANK/Y19242
PT  - Journal Article
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 0 (Calcium-Binding Proteins)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Membrane Proteins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (SYT6 protein, human)
RN  - 0 (Syt6 protein, rat)
RN  - 134193-27-4 (Synaptotagmins)
RN  - 63231-63-0 (RNA)
SB  - IM
MH  - Alternative Splicing/*genetics
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - *Calcium-Binding Proteins
MH  - Cell Membrane/genetics/metabolism
MH  - Chromosomes, Human, Pair 11/genetics
MH  - Exons/*genetics
MH  - Humans
MH  - Membrane Glycoproteins/biosynthesis/*genetics
MH  - Membrane Proteins/*genetics
MH  - Molecular Sequence Data
MH  - Nerve Tissue Proteins/biosynthesis/*genetics
MH  - Organ Specificity
MH  - RNA/analysis
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Sequence Analysis, DNA
MH  - Synaptotagmins
EDAT- 1999/11/11 00:00
MHDA- 1999/11/11 00:01
CRDT- 1999/11/11 00:00
PHST- 1999/11/11 00:00 [pubmed]
PHST- 1999/11/11 00:01 [medline]
PHST- 1999/11/11 00:00 [entrez]
AID - S0014-5793(99)01382-4 [pii]
AID - 10.1016/s0014-5793(99)01382-4 [doi]
PST - ppublish
SO  - FEBS Lett. 1999 Nov 5;460(3):417-22. doi: 10.1016/s0014-5793(99)01382-4.