PMID- 10556429
OWN - NLM
STAT- MEDLINE
DCOM- 20000127
LR  - 20190905
IS  - 0938-8990 (Print)
IS  - 0938-8990 (Linking)
VI  - 10
IP  - 11
DP  - 1999 Nov
TI  - Characterization of the Lmo4 gene encoding a LIM-only protein: genomic
      organization and comparative chromosomal mapping.
PG  - 1089-94
AB  - LIM-only (LMO) proteins are transcription regulators that function by mediating
      protein-protein interaction and include the T cell oncogenes encoding LMO1 and
      LMO2. The oncogenic functions of LMO1 and LMO2 are thought to be mediated by
      interaction with LDB1 since they form a multimeric protein complex(es). A new
      member of the Lmo family, Lmo4, has also recently been identified via its
      interaction with Ldb1. Sequence analysis of the mouse Lmo4 gene shows that it
      spans about 18 kb and consists of at least six exons, including two alternatively
      spliced 5' exons. Unlike Lmo1, the two 5' exons of Lmo4 do not encode protein.
      Comparison of the Lmo4 gene structure with the other LMO family members shows the
      exon structure of Lmo4 differs in the position of exon junctions encoding the
      second LIM domain and in a novel exon-intron junction at the penultimate codon of
      the gene. Lmo4 is thus the least conserved known member of the LIM-only family in
      both nucleotide sequence and exon structure. Physical mapping of the Lmo4/LMO4
      genes has shown mouse Lmo4 is located on Chromosome (Chr) 3 and human LMO4 on Chr
      1p22.3. This chromosome location is of interest as it occurs in a region that is 
      deleted in a number of human cancers, indicating a possible role of LMO4 in
      tumorigenesis, like its relatives LMO1 and LMO2.
FAU - Tse, E
AU  - Tse E
AD  - MRC Laboratory of Molecular Biology, Division of Protein and Nucleic Acid
      Chemistry, Hills Road, Cambridge CB2 2 QH, UK.
FAU - Grutz, G
AU  - Grutz G
FAU - Garner, A A
AU  - Garner AA
FAU - Ramsey, Y
AU  - Ramsey Y
FAU - Carter, N P
AU  - Carter NP
FAU - Copeland, N
AU  - Copeland N
FAU - Gilbert, D J
AU  - Gilbert DJ
FAU - Jenkins, N A
AU  - Jenkins NA
FAU - Agulnick, A
AU  - Agulnick A
FAU - Forster, A
AU  - Forster A
FAU - Rabbitts, T H
AU  - Rabbitts TH
LA  - eng
GR  - Wellcome Trust/United Kingdom
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Mamm Genome
JT  - Mammalian genome : official journal of the International Mammalian Genome Society
JID - 9100916
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Homeodomain Proteins)
RN  - 0 (LIM Domain Proteins)
RN  - 0 (LMO1 protein, human)
RN  - 0 (LMO2 protein, human)
RN  - 0 (LMO4 protein, human)
RN  - 0 (Lmo1 protein, mouse)
RN  - 0 (Lmo2 protein, mouse)
RN  - 0 (Lmo4 protein, mouse)
RN  - 0 (Metalloproteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Oncogene Proteins)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Adaptor Proteins, Signal Transducing
MH  - Amino Acid Sequence
MH  - Animals
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 1
MH  - DNA-Binding Proteins/genetics
MH  - Exons/genetics
MH  - Genomic Library
MH  - Homeodomain Proteins/*genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Introns/genetics
MH  - LIM Domain Proteins
MH  - Metalloproteins/genetics
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Molecular Sequence Data
MH  - Muridae
MH  - Nuclear Proteins
MH  - *Oncogene Proteins
MH  - Proto-Oncogene Proteins
MH  - Sequence Alignment
MH  - Transcription Factors/*genetics
EDAT- 1999/11/11 00:00
MHDA- 1999/11/11 00:01
CRDT- 1999/11/11 00:00
PHST- 1999/11/11 00:00 [pubmed]
PHST- 1999/11/11 00:01 [medline]
PHST- 1999/11/11 00:00 [entrez]
AID - MG99-SB100 [pii]
AID - 10.1007/s003359901167 [doi]
PST - ppublish
SO  - Mamm Genome. 1999 Nov;10(11):1089-94. doi: 10.1007/s003359901167.