PMID- 10556425
OWN - NLM
STAT- MEDLINE
DCOM- 20000127
LR  - 20190905
IS  - 0938-8990 (Print)
IS  - 0938-8990 (Linking)
VI  - 10
IP  - 11
DP  - 1999 Nov
TI  - High-resolution maps of the murine Chromosome 2 region containing the cholesterol
      gallstone locus, Lith1.
PG  - 1070-4
AB  - The Lith1 region on Chromosome (Chr) 2 contains a gene that markedly affects the 
      prevalence of cholesterol gallstones in inbred mice. We report the
      high-resolution genetic and radiation hybrid maps of the chromosomal region
      surrounding Lith1, using three resources: a DNA panel from 188 progeny from two
      reciprocal backcrosses between C57BL/6 and Mus spretus inbred strains; 423
      progeny of an N4 generation from backcrossing the susceptible C57L/J alleles at
      Lith1 into the resistant AKR/J strain; and the newly developed hamster-mouse T31 
      radiation hybrid panel. We mapped 17 microsatellite markers in the D2Mit182 to
      D2Mit14 region and two candidate genes for Lith1, the canalicular bile salt
      export pump (Bsep) also known as sister of P-glycoprotein (Spgp) and the
      low-density-lipoprotein-receptor-related gene megalin (Gp330). Both genetic maps 
      were in agreement and ordered the microsatellite markers into a 10.4 +/- 1.5 cM
      region. The high-resolution physical map revealed ordering of microsatellite
      markers and relative distances between markers in almost complete agreement with 
      the genetic maps. Mapping of Bsep revealed its location on Chr 2, homologous to
      the human chromosomal position (Nature Genet 20, 233-238, 1998). The radiation
      hybrid results also provided the highest resolution of the area containing the
      two candidate genes, which both mapped in the Lith1 region with close linkage,
      being separated by a distance of only 15 cR(3000). The total radiation hybrid map
      length of the region between D2Mit182 and D2Mit14 was 326 cR(3000), suggesting
      that 31 cR(3000) is equivalent to 1 cM in this region of Chr 2.
FAU - Bouchard, G
AU  - Bouchard G
AD  - The Jackson Laboratory, 600 Main St., Bar Harbor, Maine 04609, USA.
FAU - Nelson, H M
AU  - Nelson HM
FAU - Lammert, F
AU  - Lammert F
FAU - Rowe, L B
AU  - Rowe LB
FAU - Carey, M C
AU  - Carey MC
FAU - Paigen, B
AU  - Paigen B
LA  - eng
GR  - DK 36588/DK/NIDDK NIH HHS/United States
GR  - DK 51568/DK/NIDDK NIH HHS/United States
GR  - DK 52911/DK/NIDDK NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Mamm Genome
JT  - Mammalian genome : official journal of the International Mammalian Genome Society
JID - 9100916
RN  - 0 (ABCB11 protein, human)
RN  - 0 (ATP Binding Cassette Transporter, Subfamily B, Member 11)
RN  - 0 (ATP-Binding Cassette Transporters)
RN  - 0 (Abcb11 protein, mouse)
RN  - 0 (Genetic Markers)
RN  - 0 (Heymann Nephritis Antigenic Complex)
RN  - 0 (Membrane Glycoproteins)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - ATP Binding Cassette Transporter, Subfamily B, Member 11
MH  - ATP-Binding Cassette Transporters/*genetics
MH  - Animals
MH  - Breeding
MH  - Cholelithiasis/*genetics
MH  - *Cholesterol
MH  - *Chromosome Mapping
MH  - Cricetinae
MH  - Genetic Markers
MH  - Genetic Predisposition to Disease
MH  - Heymann Nephritis Antigenic Complex
MH  - Humans
MH  - Hybrid Cells
MH  - Membrane Glycoproteins/genetics
MH  - Mice
MH  - Mice, Inbred AKR
MH  - Mice, Inbred C57BL
MH  - Physical Chromosome Mapping
EDAT- 1999/11/11 00:00
MHDA- 1999/11/11 00:01
CRDT- 1999/11/11 00:00
PHST- 1999/11/11 00:00 [pubmed]
PHST- 1999/11/11 00:01 [medline]
PHST- 1999/11/11 00:00 [entrez]
AID - MGS2163 [pii]
AID - 10.1007/s003359901163 [doi]
PST - ppublish
SO  - Mamm Genome. 1999 Nov;10(11):1070-4. doi: 10.1007/s003359901163.