PMID- 10556287
OWN - NLM
STAT- MEDLINE
DCOM- 20000124
LR  - 20190513
IS  - 0964-6906 (Print)
IS  - 0964-6906 (Linking)
VI  - 8
IP  - 13
DP  - 1999 Dec
TI  - Two murine and human homologs of mab-21, a cell fate determination gene involved 
      in Caenorhabditis elegans neural development.
PG  - 2397-406
AB  - We report the cloning and genetic characterization of one human and two murine
      homologs of the mab-21 cell fate specification gene. mab-21 participates in the
      formation of sensory organs in the male nematode tail, and is essential for other
      developmental functions elsewhere in the Caenorhabditis elegans embryo. The
      expanding mab-21 gene family, which is strikingly conserved in evolution,
      includes two putative Drosophila members. The two mammalian genes, encoding 41
      kDa nuclear basic proteins, are expressed in partially overlapping territories in
      the embryonic brain, eye and limbs, as well as in neural crest derivatives.
      Recent genetic data implicating mab-21 as a downstream target of TGF-beta
      signaling, together with the distribution of mab-21 transcripts in the mouse
      embryo, propose these novel genes as relevant factors in various aspects of
      vertebrate neural development.
FAU - Mariani, M
AU  - Mariani M
AD  - Department of Neuroscience, San Raffaele Scientific Institute, Milan, Italy.
FAU - Baldessari, D
AU  - Baldessari D
FAU - Francisconi, S
AU  - Francisconi S
FAU - Viggiano, L
AU  - Viggiano L
FAU - Rocchi, M
AU  - Rocchi M
FAU - Zappavigna, V
AU  - Zappavigna V
FAU - Malgaretti, N
AU  - Malgaretti N
FAU - Consalez, G G
AU  - Consalez GG
LA  - eng
GR  - E.0740/Telethon/Italy
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Hum Mol Genet
JT  - Human molecular genetics
JID - 9208958
RN  - 0 (Homeodomain Proteins)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Brain/metabolism
MH  - Caenorhabditis elegans/*genetics/growth & development
MH  - Cerebellum/metabolism
MH  - Chromosome Mapping
MH  - Chromosomes, Artificial, Yeast
MH  - Chromosomes, Human, Pair 13
MH  - Chromosomes, Human, Pair 4
MH  - Cloning, Molecular
MH  - Embryo, Mammalian/metabolism
MH  - Embryo, Nonmammalian
MH  - Eye/metabolism
MH  - Gene Expression
MH  - Homeodomain Proteins/*genetics/metabolism
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Molecular Sequence Data
MH  - Phylogeny
MH  - Sequence Homology, Amino Acid
EDAT- 1999/11/11 00:00
MHDA- 1999/11/11 00:01
CRDT- 1999/11/11 00:00
PHST- 1999/11/11 00:00 [pubmed]
PHST- 1999/11/11 00:01 [medline]
PHST- 1999/11/11 00:00 [entrez]
AID - ddc291 [pii]
AID - 10.1093/hmg/8.13.2397 [doi]
PST - ppublish
SO  - Hum Mol Genet. 1999 Dec;8(13):2397-406. doi: 10.1093/hmg/8.13.2397.