PMID- 10556217
OWN - NLM
STAT- MEDLINE
DCOM- 19991130
LR  - 20181130
IS  - 0006-4971 (Print)
IS  - 0006-4971 (Linking)
VI  - 94
IP  - 9
DP  - 1999 Nov 1
TI  - TRK-fused gene (TFG) is a new partner of ALK in anaplastic large cell lymphoma
      producing two structurally different TFG-ALK translocations.
PG  - 3265-8
AB  - Anaplastic large cell lymphoma (ALCL) is associated with the t(2;5)(p23;q35),
      which generates the NPM-ALK fusion gene encoding an 80-kD protein. Several
      studies have suggested that genes other than NPM may be fused to the ALK gene.
      Here we have identified TRK-fused gene (TFG) as a new ALK partner in 2 ALCL, 1 of
      which exhibited a t(2;3)(p23;q21). In these cases, TFG was involved in 2
      different fusion genes, TFG-ALK(S) and TFG-ALK(L), coding respectively 85-kD and 
      97-kD chimeric proteins. The ALK breakpoint in these translocations was the same 
      as in the classic t(2;5) translocation. These 2 proteins were both active in an
      in vitro tyrosine kinase assay showing that the new cloned cDNA sequences are
      translated into chimeric proteins with functional activity. These findings
      indicate that TFG can provide an alternative to NPM as a fusion partner
      responsible for activation of the ALK and the pathogenesis of ALCL.
FAU - Hernandez, L
AU  - Hernandez L
AD  - Laboratory of Pathology, Hospital Clinic, Institut d'Investigacions Biomediques
      August Pi i Sunyer, University of Barcelona, Barcelona, Spain.
FAU - Pinyol, M
AU  - Pinyol M
FAU - Hernandez, S
AU  - Hernandez S
FAU - Bea, S
AU  - Bea S
FAU - Pulford, K
AU  - Pulford K
FAU - Rosenwald, A
AU  - Rosenwald A
FAU - Lamant, L
AU  - Lamant L
FAU - Falini, B
AU  - Falini B
FAU - Ott, G
AU  - Ott G
FAU - Mason, D Y
AU  - Mason DY
FAU - Delsol, G
AU  - Delsol G
FAU - Campo, E
AU  - Campo E
LA  - eng
SI  - GENBANK/AF125093
SI  - GENBANK/AF143407
GR  - Wellcome Trust/United Kingdom
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
RN  - 0 (DNA, Neoplasm)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Recombinant Fusion Proteins)
RN  - 117896-08-9 (nucleophosmin)
RN  - EC 2.7.10.1 (ALK protein, human)
RN  - EC 2.7.10.1 (Anaplastic Lymphoma Kinase)
RN  - EC 2.7.10.1 (Protein-Tyrosine Kinases)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
SB  - AIM
SB  - IM
MH  - Adult
MH  - Amino Acid Sequence
MH  - Anaplastic Lymphoma Kinase
MH  - Artificial Gene Fusion
MH  - Base Sequence
MH  - *Chromosomes, Human, Pair 2
MH  - *Chromosomes, Human, Pair 5
MH  - DNA, Neoplasm/genetics
MH  - Humans
MH  - Lymphoma, Large B-Cell, Diffuse/*genetics/pathology
MH  - Male
MH  - Molecular Sequence Data
MH  - Nuclear Proteins/genetics
MH  - Protein-Tyrosine Kinases/*genetics
MH  - Receptor Protein-Tyrosine Kinases
MH  - Recombinant Fusion Proteins/genetics
MH  - *Translocation, Genetic
EDAT- 1999/11/11 00:00
MHDA- 1999/11/11 00:01
CRDT- 1999/11/11 00:00
PHST- 1999/11/11 00:00 [pubmed]
PHST- 1999/11/11 00:01 [medline]
PHST- 1999/11/11 00:00 [entrez]
PST - ppublish
SO  - Blood. 1999 Nov 1;94(9):3265-8.