PMID- 10555147
OWN - NLM
STAT- MEDLINE
DCOM- 19991123
LR  - 20191210
IS  - 0092-8674 (Print)
IS  - 0092-8674 (Linking)
VI  - 99
IP  - 3
DP  - 1999 Oct 29
TI  - Chronic phospholamban-sarcoplasmic reticulum calcium ATPase interaction is the
      critical calcium cycling defect in dilated cardiomyopathy.
PG  - 313-22
AB  - Dilated cardiomyopathy and end-stage heart failure result in multiple defects in 
      cardiac excitation-contraction coupling. Via complementation of a genetically
      based mouse model of dilated cardiomyopathy, we now provide evidence that
      progressive chamber dilation and heart failure are dependent on a Ca2+ cycling
      defect in the cardiac sarcoplasmic reticulum. The ablation of a muscle-specific
      sarcoplasmic reticulum Ca2+ ATPase (SERCA2a) inhibitor, phospholamban, rescued
      the spectrum of phenotypes that resemble human heart failure. Inhibition of
      phospholamban-SERCA2a interaction via in vivo expression of a phospholamban point
      mutant dominantly activated the contractility of ventricular muscle cells. Thus, 
      interfering with phospholamban-SERCA2a interaction may provide a novel
      therapeutic approach for preventing the progression of dilated cardiomyopathy.
FAU - Minamisawa, S
AU  - Minamisawa S
AD  - Department of Medicine, and Center for Molecular Genetics, University of
      California at San Diego, La Jolla 92093-0613C, USA.
FAU - Hoshijima, M
AU  - Hoshijima M
FAU - Chu, G
AU  - Chu G
FAU - Ward, C A
AU  - Ward CA
FAU - Frank, K
AU  - Frank K
FAU - Gu, Y
AU  - Gu Y
FAU - Martone, M E
AU  - Martone ME
FAU - Wang, Y
AU  - Wang Y
FAU - Ross, J Jr
AU  - Ross J Jr
FAU - Kranias, E G
AU  - Kranias EG
FAU - Giles, W R
AU  - Giles WR
FAU - Chien, K R
AU  - Chien KR
LA  - eng
GR  - HL26057/HL/NHLBI NIH HHS/United States
GR  - HL52318/HL/NHLBI NIH HHS/United States
GR  - P40RR12358/RR/NCRR NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Cell
JT  - Cell
JID - 0413066
RN  - 0 (Calcium-Binding Proteins)
RN  - 0 (phospholamban)
RN  - EC 7.2.2.10 (Calcium-Transporting ATPases)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Animals
MH  - Calcium/*metabolism
MH  - Calcium-Binding Proteins/deficiency/*genetics/*metabolism
MH  - Calcium-Transporting ATPases/antagonists & inhibitors/*metabolism
MH  - Cardiomyopathy, Dilated/*genetics/pathology/*physiopathology
MH  - Disease Models, Animal
MH  - Disease Progression
MH  - Heart/physiology/*physiopathology
MH  - Hemodynamics/genetics/*physiology
MH  - Homeostasis
MH  - Humans
MH  - Mice
MH  - Mice, Knockout
MH  - Myocardial Contraction
MH  - Myocardium/pathology
MH  - Sarcoplasmic Reticulum/*enzymology
MH  - Ventricular Function, Left
EDAT- 1999/11/11 09:00
MHDA- 2001/03/28 10:01
CRDT- 1999/11/11 09:00
PHST- 1999/11/11 09:00 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1999/11/11 09:00 [entrez]
AID - S0092-8674(00)81662-1 [pii]
AID - 10.1016/s0092-8674(00)81662-1 [doi]
PST - ppublish
SO  - Cell. 1999 Oct 29;99(3):313-22. doi: 10.1016/s0092-8674(00)81662-1.