PMID- 10552935
OWN - NLM
STAT- MEDLINE
DCOM- 20000214
LR  - 20101004
IS  - 0888-7543 (Print)
IS  - 0888-7543 (Linking)
VI  - 61
IP  - 3
DP  - 1999 Nov 1
TI  - Human aiolos, an ikaros-related zinc finger DNA binding protein: cDNA cloning,
      tissue expression pattern, and chromosomal mapping.
PG  - 326-9
AB  - The Ikaros gene (symbol ZNFN1A1) encodes the hematopoietic zinc finger DNA
      binding protein, which is now recognized as a central regulator of lymphoid
      differentiation and has been implicated in leukemogenesis. Recently, an
      Ikaros-related zinc finger protein, called Aiolos (ZNFN1A3), has been identified 
      and characterized, thus establishing the presence of a gene family whose members 
      may be hematopoietic transcription factors. Among Aiolos-mutant mice, development
      of B-cell lymphoma was frequently seen. As an initial approach to examining the
      possible involvement of Aiolos in the pathogenesis of human lymphoid
      proliferative disease, we isolated cDNA clones for human Aiolos from a B-cell
      cDNA library. The human Aiolos protein predicted from the cDNA sequence consists 
      of 509 amino acid residues and shares 86% sequence identity with its mouse
      counterpart. As in the case with mouse Aiolos, no isoform for human Aiolos has
      been found. Northern blot analysis of various human tissues revealed that the
      Aiolos transcripts are expressed most strongly in peripheral blood leukocytes,
      the spleen, and the thymus, supporting the notion that Aiolos plays an important 
      role in lymphoid lineages. Fluorescence in situ hybridization using a BAC clone
      established that the Aiolos gene is mapped to human chromosome band 17q11.2.
CI  - Copyright 1999 Academic Press.
FAU - Hosokawa, Y
AU  - Hosokawa Y
AD  - Laboratory of Chemotherapy, Aichi Cancer Center Research Institute, Nagoya,
      464-8681, Japan. yhosokaw@aichicc.pref.aichi.jp
FAU - Maeda, Y
AU  - Maeda Y
FAU - Takahashi, E i
AU  - Takahashi Ei
FAU - Suzuki, M
AU  - Suzuki M
FAU - Seto, M
AU  - Seto M
LA  - eng
SI  - GENBANK/AF129512
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Genomics
JT  - Genomics
JID - 8800135
RN  - 0 (DNA, Complementary)
RN  - 0 (IKZF3 protein, human)
RN  - 0 (Ikzf3 protein, mouse)
RN  - 0 (Trans-Activators)
RN  - 0 (Transcription Factors)
RN  - 148971-36-2 (Ikaros Transcription Factor)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Blotting, Northern
MH  - Chromosome Mapping
MH  - Chromosomes, Human, Pair 17/*genetics
MH  - *Cloning, Molecular
MH  - DNA, Complementary/genetics
MH  - Gene Expression Profiling
MH  - Humans
MH  - Ikaros Transcription Factor
MH  - In Situ Hybridization, Fluorescence
MH  - Lymphoma, B-Cell/genetics
MH  - Mice
MH  - Molecular Sequence Data
MH  - Trans-Activators/*biosynthesis/chemistry/*genetics
MH  - Transcription Factors
MH  - Tumor Cells, Cultured
EDAT- 1999/11/24 09:00
MHDA- 2000/02/19 09:00
CRDT- 1999/11/24 09:00
PHST- 1999/11/24 09:00 [pubmed]
PHST- 2000/02/19 09:00 [medline]
PHST- 1999/11/24 09:00 [entrez]
AID - 10.1006/geno.1999.5949 [doi]
AID - S0888754399959499 [pii]
PST - ppublish
SO  - Genomics. 1999 Nov 1;61(3):326-9. doi: 10.1006/geno.1999.5949.