PMID- 10552934
OWN - NLM
STAT- MEDLINE
DCOM- 20000214
LR  - 20131121
IS  - 0888-7543 (Print)
IS  - 0888-7543 (Linking)
VI  - 61
IP  - 3
DP  - 1999 Nov 1
TI  - PFM1 (PRDM4), a new member of the PR-domain family, maps to a tumor suppressor
      locus on human chromosome 12q23-q24.1.
PG  - 319-25
AB  - The PR domain, first noted as the PRDI-BF1 (HGMW-approved symbol PRDM1) and RIZ
      (HGMW-approved symbol PRDM2) homologous region, defines a small family of
      transcription factors involved in cell differentiation and tumorigenesis. The
      shared role of this family in human cancer raises considerable interest in
      identifying novel members of this family as candidate cancer genes. This paper
      describes a new human PR family member, designated PFM1 (HGMW-approved symbol
      PRDM4). A full-length PFM1 cDNA of 3902 nucleotides has been isolated based on
      its homology to the PR domain. It encodes an open reading frame of 796 amino
      acids and contains a PR domain in the middle region and six zinc finger motifs at
      the carboxyl-terminus. Several PFM1 mRNA species of different lengths were
      detected by Northern blot analysis, one species of which lacked the
      amino-terminal region of PFM1 and part of the PR domain. The major PFM1 mRNA
      species of approximately 4.6 kb was widely expressed but more abundant in ovary, 
      testis, pancreas, brain, heart, and prostate. PFM1 mRNA levels were highly
      elevated in PC12 cells treated with NGF, suggesting a role for PFM1 in the NGF
      signal transduction pathway. STS marker and radiation hybrid analyses mapped PFM1
      to human chromosome 12q23-q24.1, a region thought to harbor tumor suppressor
      genes for ovarian, gastric, and pancreatic cancers. These results suggest a role 
      for PFM1 in cell differentiation and tumor suppression, remarkably consistent
      with the known functions of the PR-domain family.
CI  - Copyright 1999 Academic Press.
FAU - Yang, X H
AU  - Yang XH
AD  - Program in Oncogenes and Tumor Suppressor Genes, The Burnham Institute, La Jolla,
      California, 92037, USA.
FAU - Huang, S
AU  - Huang S
LA  - eng
SI  - GENBANK/AF144757
GR  - R01CA76146/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Genomics
JT  - Genomics
JID - 8800135
RN  - 0 (DNA, Complementary)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (PRDM4 protein, human)
RN  - 0 (Transcription Factors)
RN  - 0 (Tumor Suppressor Proteins)
SB  - IM
MH  - Amino Acid Sequence
MH  - Base Sequence
MH  - Blotting, Northern
MH  - *Chromosome Mapping
MH  - Chromosomes, Human, Pair 12/*genetics
MH  - DNA, Complementary/genetics
MH  - DNA-Binding Proteins
MH  - Expressed Sequence Tags
MH  - Gene Expression Profiling
MH  - *Genes, Tumor Suppressor
MH  - Humans
MH  - Molecular Sequence Data
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Transcription Factors/chemistry/*genetics/metabolism
MH  - *Tumor Suppressor Proteins
EDAT- 1999/11/24 09:00
MHDA- 2000/02/19 09:00
CRDT- 1999/11/24 09:00
PHST- 1999/11/24 09:00 [pubmed]
PHST- 2000/02/19 09:00 [medline]
PHST- 1999/11/24 09:00 [entrez]
AID - 10.1006/geno.1999.5967 [doi]
AID - S0888-7543(99)95967-0 [pii]
PST - ppublish
SO  - Genomics. 1999 Nov 1;61(3):319-25. doi: 10.1006/geno.1999.5967.