PMID- 10552933
OWN - NLM
STAT- MEDLINE
DCOM- 20000214
LR  - 20091119
IS  - 0888-7543 (Print)
IS  - 0888-7543 (Linking)
VI  - 61
IP  - 3
DP  - 1999 Nov 1
TI  - Cloning, characterization, and chromosome mapping of RPS6KC1, a novel putative
      member of the ribosome protein S6 kinase family, to chromosome 12q12-q13.1.
PG  - 314-8
AB  - A novel cDNA encoding a putative Ser/Thr protein kinase was isolated from a human
      skeletal muscle cDNA library. It contains an open reading frame that extends from
      nt 104 to 1510 and codes for a protein of 469 amino acids. A catalytic domain
      containing the conserved residues of the Ser/Thr protein kinase, especially human
      ribosome protein S6 kinase (RSK), was found to be located in the C-terminal end
      of the deduced protein. The gene was mapped to human chromosome 12q12-q13.1 by
      fluorescence in situ hybridization, and this result was confirmed with the
      Radiation Hybrid GB4 panel. Northern hybridization showed that the novel gene is 
      expressed in all 16 human tissues tested with especially strong expression in
      testis, skeletal muscle, and brain, whereas weak expression was detected in
      kidney, thymus, small intestine, liver, lung, heart, and colon.
CI  - Copyright 1999 Academic Press.
FAU - Zhang, H
AU  - Zhang H
AD  - Institute of Genetics, Fudan University, Shanghai, 200433, People's Republic of
      China.
FAU - Yu, L
AU  - Yu L
FAU - Mao, N
AU  - Mao N
FAU - Fu, Q
AU  - Fu Q
FAU - Tu, Q
AU  - Tu Q
FAU - Gao, J
AU  - Gao J
FAU - Zhao, S
AU  - Zhao S
LA  - eng
SI  - GENBANK/AF037447
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Genomics
JT  - Genomics
JID - 8800135
RN  - 0 (DNA, Complementary)
RN  - EC 2.7.11.1 (Ribosomal Protein S6 Kinases)
SB  - IM
MH  - Amino Acid Sequence
MH  - Base Sequence
MH  - Blotting, Northern
MH  - *Chromosome Mapping
MH  - Chromosomes, Human, Pair 12/*genetics
MH  - *Cloning, Molecular
MH  - DNA, Complementary/genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Molecular Sequence Data
MH  - Ribosomal Protein S6 Kinases/chemistry/*genetics/metabolism
MH  - Sequence Alignment
EDAT- 1999/11/24 09:00
MHDA- 2000/02/19 09:00
CRDT- 1999/11/24 09:00
PHST- 1999/11/24 09:00 [pubmed]
PHST- 2000/02/19 09:00 [medline]
PHST- 1999/11/24 09:00 [entrez]
AID - 10.1006/geno.1999.5963 [doi]
AID - S0888-7543(99)95963-3 [pii]
PST - ppublish
SO  - Genomics. 1999 Nov 1;61(3):314-8. doi: 10.1006/geno.1999.5963.