PMID- 10550327
OWN - NLM
STAT- MEDLINE
DCOM- 19991130
LR  - 20220409
IS  - 0002-9440 (Print)
IS  - 0002-9440 (Linking)
VI  - 155
IP  - 5
DP  - 1999 Nov
TI  - High expression of doublecortin and KIAA0369 protein in fetal brain suggests
      their specific role in neuronal migration.
PG  - 1713-21
AB  - The X-linked subcortical laminar heterotopia and lissencephaly syndrome is a
      disorder of neuronal migration caused by a mutation in XLIS, a recently cloned
      gene on chromosome Xq22.3-q23. The predicted protein product for XLIS,
      doublecortin (DC), shows high homology to a putative calcium calmodulin-dependent
      kinase, KIAA0369 protein (KI). Here we identified DC and KI in the brains of
      human and rat fetuses by immunochemical and immunohistochemical means. In this
      study, Western blotting demonstrated that both DC and KI are specific to the
      nervous system and are abundant during the fetal period, around 20 gestational
      weeks in humans and embryonic days 17 to 20 in rats. Immunostaining of the
      developing neocortex disclosed localization of DC and KI immunoreactivities in
      neuronal cell bodies and processes in the zones of ongoing neuronal migration.
      Although KI showed a somewhat wider distribution than DC, the temporal and
      spatial patterns of their expression were similar. These results suggest that DC 
      and KI participate in a common signaling pathway regulating neuronal migration.
FAU - Mizuguchi, M
AU  - Mizuguchi M
AD  - Department of Pediatrics, Jichi Medical School, Tochigi, Japan.
FAU - Qin, J
AU  - Qin J
FAU - Yamada, M
AU  - Yamada M
FAU - Ikeda, K
AU  - Ikeda K
FAU - Takashima, S
AU  - Takashima S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Pathol
JT  - The American journal of pathology
JID - 0370502
RN  - 0 (Dcx protein, rat)
RN  - 0 (Doublecortin Domain Proteins)
RN  - 0 (Doublecortin Protein)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Microtubule-Associated Proteins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Neuropeptides)
RN  - EC 2.7.1.11 (DCLK1 protein, human)
RN  - EC 2.7.1.11 (Doublecortin-Like Kinases)
RN  - EC 2.7.11.1 (Dclk1 protein, rat)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
RN  - EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinases)
SB  - IM
MH  - Animals
MH  - Brain/cytology/embryology/*metabolism
MH  - Calcium-Calmodulin-Dependent Protein Kinases/*biosynthesis
MH  - *Cell Movement
MH  - Doublecortin Domain Proteins
MH  - Doublecortin Protein
MH  - Doublecortin-Like Kinases
MH  - Embryonic and Fetal Development
MH  - Humans
MH  - Intracellular Signaling Peptides and Proteins
MH  - *Microtubule-Associated Proteins
MH  - Nerve Tissue Proteins/metabolism
MH  - Neurons/*cytology/*metabolism
MH  - Neuropeptides/*biosynthesis
MH  - *Protein Serine-Threonine Kinases
MH  - Rats
PMC - PMC1866984
EDAT- 1999/11/07 00:00
MHDA- 1999/11/07 00:01
CRDT- 1999/11/07 00:00
PHST- 1999/11/07 00:00 [pubmed]
PHST- 1999/11/07 00:01 [medline]
PHST- 1999/11/07 00:00 [entrez]
AID - S0002-9440(10)65486-7 [pii]
AID - 10.1016/S0002-9440(10)65486-7 [doi]
PST - ppublish
SO  - Am J Pathol. 1999 Nov;155(5):1713-21. doi: 10.1016/S0002-9440(10)65486-7.