PMID- 10549624
OWN - NLM
STAT- MEDLINE
DCOM- 19991123
LR  - 20190915
IS  - 1074-7613 (Print)
IS  - 1074-7613 (Linking)
VI  - 11
IP  - 4
DP  - 1999 Oct
TI  - B7h, a novel costimulatory homolog of B7.1 and B7.2, is induced by TNFalpha.
PG  - 423-32
AB  - In a screen to identify genes induced by NF-kappaB/Rel transcription factors, we 
      cloned a novel gene, b7h, that is a close homolog of B7 costimulatory ligands
      expressed on antigen-presenting cells. B7h can costimulate proliferation of
      purified T cells through a receptor on T cells distinct from CD28 or CTLA-4.
      Surprisingly, although B7h is expressed in unstimulated B cells, its expression
      is induced in both 3T3 cells and embryonic fibroblasts treated with TNFalpha, and
      it is upregulated in nonlymphoid tissues of mice treated with LPS, a potent
      activator of TNFalpha. These data define a novel costimulatory ligand for T cells
      and suggest that induction of B7h by TNFalpha may function as a mechanism to
      directly augment recognition of self during inflammation.
FAU - Swallow, M M
AU  - Swallow MM
AD  - Molecular and Cell Biology Department, University of California, Berkeley 94720, 
      USA.
FAU - Wallin, J J
AU  - Wallin JJ
FAU - Sha, W C
AU  - Sha WC
LA  - eng
GR  - AI42252/AI/NIAID NIH HHS/United States
GR  - GM07232-22/GM/NIGMS NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Immunity
JT  - Immunity
JID - 9432918
RN  - 0 (B7-1 Antigen)
RN  - 0 (DNA, Complementary)
RN  - 0 (Icosl protein, mouse)
RN  - 0 (Inducible T-Cell Co-Stimulator Ligand)
RN  - 0 (Ligands)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (NF-kappa B)
RN  - 0 (Proteins)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - EC 6.- (Ligases)
RN  - EC 6.- (guanosine 3',5'-polyphosphate synthetases)
SB  - IM
MH  - 3T3 Cells/drug effects/metabolism
MH  - Amino Acid Sequence
MH  - Animals
MH  - *Antigen Presentation
MH  - B-Lymphocytes/drug effects/*immunology/metabolism
MH  - B7-1 Antigen/chemistry/genetics
MH  - Base Sequence
MH  - CHO Cells
MH  - Cricetinae
MH  - Cricetulus
MH  - DNA, Complementary/genetics
MH  - Fibroblasts/drug effects/metabolism
MH  - Gene Expression Regulation/drug effects
MH  - Gene Library
MH  - Genes
MH  - Inducible T-Cell Co-Stimulator Ligand
MH  - Inflammation
MH  - Ligands
MH  - Ligases/metabolism
MH  - Lipopolysaccharides/immunology
MH  - *Lymphocyte Activation
MH  - Lymphocyte Cooperation
MH  - Mice
MH  - Molecular Sequence Data
MH  - Multigene Family
MH  - NF-kappa B/metabolism
MH  - Protein Biosynthesis
MH  - Proteins/genetics/*immunology
MH  - Sequence Alignment
MH  - Sequence Homology, Amino Acid
MH  - Subtraction Technique
MH  - T-Lymphocytes/*immunology
MH  - Tumor Necrosis Factor-alpha/*pharmacology
EDAT- 1999/11/05 00:00
MHDA- 1999/11/05 00:01
CRDT- 1999/11/05 00:00
PHST- 1999/11/05 00:00 [pubmed]
PHST- 1999/11/05 00:01 [medline]
PHST- 1999/11/05 00:00 [entrez]
AID - S1074-7613(00)80117-X [pii]
AID - 10.1016/s1074-7613(00)80117-x [doi]
PST - ppublish
SO  - Immunity. 1999 Oct;11(4):423-32. doi: 10.1016/s1074-7613(00)80117-x.