PMID- 10549295
OWN - NLM
STAT- MEDLINE
DCOM- 19991126
LR  - 20190915
IS  - 1097-2765 (Print)
IS  - 1097-2765 (Linking)
VI  - 4
IP  - 4
DP  - 1999 Oct
TI  - Hedgehog movement is regulated through tout velu-dependent synthesis of a heparan
      sulfate proteoglycan.
PG  - 633-9
AB  - Hedgehog (Hh) molecules play critical roles during development as a morphogen,
      and therefore their distribution must be regulated. Hh proteins undergo several
      modifications that tether them to the membrane. We have previously identified
      tout velu (ttv), a homolog of the mammalian EXT tumor suppressor gene family, as 
      a gene required for movement of Hh. In this paper, we present in vivo evidence
      that ttv is involved in heparan sulfate proteoglycan (HSPG) biosynthesis,
      suggesting that HSPGs control Hh distribution. In contrast to mutants in other
      HSPG biosynthesis genes, the activity of the HSPG-dependent FGF and Wingless
      signaling pathways are not affected in ttv mutants. This demonstrates an
      unexpected level of specificity in the regulation of the distribution of
      extracellular signals by HSPGs.
FAU - The, I
AU  - The I
AD  - Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.
FAU - Bellaiche, Y
AU  - Bellaiche Y
FAU - Perrimon, N
AU  - Perrimon N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Mol Cell
JT  - Molecular cell
JID - 9802571
RN  - 0 (Biomarkers)
RN  - 0 (Drosophila Proteins)
RN  - 0 (Hedgehog Proteins)
RN  - 0 (Heparan Sulfate Proteoglycans)
RN  - 0 (Insect Proteins)
RN  - 0 (Membrane Proteins)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (TTV protein, Drosophila)
RN  - 0 (Wnt1 Protein)
RN  - 0 (wg protein, Drosophila)
RN  - 149291-21-4 (hh protein, Drosophila)
RN  - 62031-54-3 (Fibroblast Growth Factors)
SB  - IM
MH  - Animals
MH  - Biomarkers
MH  - Drosophila/embryology
MH  - *Drosophila Proteins
MH  - Fibroblast Growth Factors/metabolism
MH  - Gene Expression Regulation
MH  - Hedgehog Proteins
MH  - Heparan Sulfate Proteoglycans/*biosynthesis/metabolism
MH  - Immunohistochemistry
MH  - Insect Proteins/*metabolism
MH  - Membrane Proteins/*genetics/metabolism
MH  - Proto-Oncogene Proteins/metabolism
MH  - Signal Transduction
MH  - Wnt1 Protein
EDAT- 1999/11/05 00:00
MHDA- 1999/11/05 00:01
CRDT- 1999/11/05 00:00
PHST- 1999/11/05 00:00 [pubmed]
PHST- 1999/11/05 00:01 [medline]
PHST- 1999/11/05 00:00 [entrez]
AID - S1097-2765(00)80214-2 [pii]
AID - 10.1016/s1097-2765(00)80214-2 [doi]
PST - ppublish
SO  - Mol Cell. 1999 Oct;4(4):633-9. doi: 10.1016/s1097-2765(00)80214-2.