PMID- 10549293
OWN - NLM
STAT- MEDLINE
DCOM- 19991126
LR  - 20190915
IS  - 1097-2765 (Print)
IS  - 1097-2765 (Linking)
VI  - 4
IP  - 4
DP  - 1999 Oct
TI  - Ubiquitin-related proteins regulate interaction of vimentin intermediate
      filaments with the plasma membrane.
PG  - 619-25
AB  - Integrin-associated protein (IAP, CD47) is a plasma membrane receptor for
      thrombospondins and signal regulatory proteins (SIRPs) that has an essential role
      in host defense through its association with integrins. The IAP gene encodes
      alternatively spliced carboxyterminal cytoplasmic tails that have no previously
      described function. IAP cytoplasmic tails can bind two related proteins that
      mediate interaction between IAP and vimentin-containing intermediate filaments,
      named proteins linking IAP with cytoskeleton (PLICs). Integrins interact with
      PLICs indirectly, through IAP. Transfection of PLICs induces redistribution of
      vimentin and cell spreading in IAP-expressing cells. This novel connection
      between plasma membrane and cytoskeleton is likely to be significant in many
      adhesion-dependent cell functions.
FAU - Wu, A L
AU  - Wu AL
AD  - Division of Infectious Diseases, Washington University School of Medicine, St.
      Louis, Missouri 63110, USA.
FAU - Wang, J
AU  - Wang J
FAU - Zheleznyak, A
AU  - Zheleznyak A
FAU - Brown, E J
AU  - Brown EJ
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Mol Cell
JT  - Molecular cell
JID - 9802571
RN  - 0 (Antigens, CD)
RN  - 0 (CD47 Antigen)
RN  - 0 (Carrier Proteins)
RN  - 0 (Cd47 protein, mouse)
RN  - 0 (Cell Cycle Proteins)
RN  - 0 (Receptors, Vitronectin)
RN  - 0 (UBQLN1 protein, human)
RN  - 0 (UBQLN2 protein, human)
RN  - 0 (Ubiquitins)
RN  - 0 (Vimentin)
SB  - IM
MH  - 3T3 Cells
MH  - Alternative Splicing/genetics
MH  - Amino Acid Sequence
MH  - Animals
MH  - Antigens, CD/*genetics/metabolism
MH  - CD47 Antigen
MH  - Carrier Proteins/*genetics/metabolism
MH  - Cell Adhesion
MH  - *Cell Cycle Proteins
MH  - Cell Membrane/*metabolism
MH  - Intermediate Filaments/metabolism
MH  - Mice
MH  - Molecular Sequence Data
MH  - Receptors, Vitronectin/metabolism
MH  - Transfection
MH  - Tumor Cells, Cultured
MH  - Ubiquitins/genetics/*metabolism
MH  - Vimentin/*metabolism
EDAT- 1999/11/05 00:00
MHDA- 1999/11/05 00:01
CRDT- 1999/11/05 00:00
PHST- 1999/11/05 00:00 [pubmed]
PHST- 1999/11/05 00:01 [medline]
PHST- 1999/11/05 00:00 [entrez]
AID - S1097-2765(00)80212-9 [pii]
AID - 10.1016/s1097-2765(00)80212-9 [doi]
PST - ppublish
SO  - Mol Cell. 1999 Oct;4(4):619-25. doi: 10.1016/s1097-2765(00)80212-9.