PMID- 10549288
OWN - NLM
STAT- MEDLINE
DCOM- 19991126
LR  - 20190915
IS  - 1097-2765 (Print)
IS  - 1097-2765 (Linking)
VI  - 4
IP  - 4
DP  - 1999 Oct
TI  - Triggering cell death: the crystal structure of Apo2L/TRAIL in a complex with
      death receptor 5.
PG  - 563-71
AB  - Formation of a complex between Apo2L (also called TRAIL) and its signaling
      receptors, DR4 and DR5, triggers apoptosis by inducing the oligomerization of
      intracellular death domains. We report the crystal structure of the complex
      between Apo2L and the ectodomain of DR5. The structure shows three elongated
      receptors snuggled into long crevices between pairs of monomers of the
      homotrimeric ligand. The interface is divided into two distinct patches, one near
      the bottom of the complex close to the receptor cell surface and one near the
      top. Both patches contain residues that are critical for high-affinity binding. A
      comparison to the structure of the lymphotoxin-receptor complex suggests general 
      principles of binding and specificity for ligand recognition in the TNF receptor 
      superfamily.
FAU - Hymowitz, S G
AU  - Hymowitz SG
AD  - Department of Protein Engineering, Genentech, Inc., South San Francisco,
      California 94080, USA.
FAU - Christinger, H W
AU  - Christinger HW
FAU - Fuh, G
AU  - Fuh G
FAU - Ultsch, M
AU  - Ultsch M
FAU - O'Connell, M
AU  - O'Connell M
FAU - Kelley, R F
AU  - Kelley RF
FAU - Ashkenazi, A
AU  - Ashkenazi A
FAU - de Vos, A M
AU  - de Vos AM
LA  - eng
SI  - PDB/1D0G
PT  - Journal Article
PL  - United States
TA  - Mol Cell
JT  - Molecular cell
JID - 9802571
RN  - 0 (Apoptosis Regulatory Proteins)
RN  - 0 (Lymphotoxin-alpha)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Peptide Fragments)
RN  - 0 (Receptors, TNF-Related Apoptosis-Inducing Ligand)
RN  - 0 (Receptors, Tumor Necrosis Factor)
RN  - 0 (Recombinant Proteins)
RN  - 0 (TNF-Related Apoptosis-Inducing Ligand)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Amino Acid Sequence
MH  - *Apoptosis
MH  - Apoptosis Regulatory Proteins
MH  - Cell Line
MH  - Crystallography, X-Ray
MH  - Escherichia coli
MH  - Lymphotoxin-alpha/chemistry
MH  - Membrane Glycoproteins/*chemistry
MH  - Models, Molecular
MH  - Molecular Conformation
MH  - Molecular Sequence Data
MH  - Peptide Fragments/chemistry
MH  - Protein Binding
MH  - Protein Structure, Secondary
MH  - Receptors, TNF-Related Apoptosis-Inducing Ligand
MH  - Receptors, Tumor Necrosis Factor/*chemistry/genetics
MH  - Recombinant Proteins/chemistry
MH  - Sequence Alignment
MH  - TNF-Related Apoptosis-Inducing Ligand
MH  - Tumor Necrosis Factor-alpha/*chemistry
EDAT- 1999/11/05 00:00
MHDA- 1999/11/05 00:01
CRDT- 1999/11/05 00:00
PHST- 1999/11/05 00:00 [pubmed]
PHST- 1999/11/05 00:01 [medline]
PHST- 1999/11/05 00:00 [entrez]
AID - S1097-2765(00)80207-5 [pii]
AID - 10.1016/s1097-2765(00)80207-5 [doi]
PST - ppublish
SO  - Mol Cell. 1999 Oct;4(4):563-71. doi: 10.1016/s1097-2765(00)80207-5.