PMID- 10549281
OWN - NLM
STAT- MEDLINE
DCOM- 19991126
LR  - 20190915
IS  - 1097-2765 (Print)
IS  - 1097-2765 (Linking)
VI  - 4
IP  - 4
DP  - 1999 Oct
TI  - Regulation of Wnt signaling by Sox proteins: XSox17 alpha/beta and XSox3
      physically interact with beta-catenin.
PG  - 487-98
AB  - Using a functional screen in Xenopus embryos, we identified a novel function for 
      the HMG box protein XSox17 beta. Ectopic expression of XSox17 beta ventralizes
      embryos by inhibiting the Wnt pathway downstream of beta-catenin but upstream of 
      the Wnt-responsive gene Siamois. XSox17 beta also represses transactivation of a 
      TCF/LEF-dependent reporter construct by Wnt and beta-catenin. In animal cap
      experiments, it both activates transcription of endodermal genes and represses
      beta-catenin-stimulated expression of dorsal genes. The inhibition activity of
      XSox17 beta maps to a region C-terminal to the HMG box; this region of XSox17
      beta physically interacts with the Armadillo repeats of beta-catenin. Two
      additional Sox proteins, XSox17 alpha and XSox3, likewise bind to beta-catenin
      and inhibit its TCF-mediated signaling activity. These results reveal an
      unexpected mechanism by which Sox proteins can modulate Wnt signaling pathways.
FAU - Zorn, A M
AU  - Zorn AM
AD  - Wellcome Trust/Cancer Research Campaign Institute of Cancer and Developmental
      Biology, Cambridge. amz@mole.bio.cam.ac.uk
FAU - Barish, G D
AU  - Barish GD
FAU - Williams, B O
AU  - Williams BO
FAU - Lavender, P
AU  - Lavender P
FAU - Klymkowsky, M W
AU  - Klymkowsky MW
FAU - Varmus, H E
AU  - Varmus HE
LA  - eng
GR  - GM54001/GM/NIGMS NIH HHS/United States
GR  - Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Mol Cell
JT  - Molecular cell
JID - 9802571
RN  - 0 (CTNNB1 protein, Xenopus)
RN  - 0 (Cytoskeletal Proteins)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (High Mobility Group Proteins)
RN  - 0 (Homeodomain Proteins)
RN  - 0 (Proteins)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Repressor Proteins)
RN  - 0 (SIA1 protein, Xenopus)
RN  - 0 (SOXB1 Transcription Factors)
RN  - 0 (SOXF Transcription Factors)
RN  - 0 (Sox3 protein, Xenopus)
RN  - 0 (Trans-Activators)
RN  - 0 (Transcription Factors)
RN  - 0 (Wnt Proteins)
RN  - 0 (Xenopus Proteins)
RN  - 0 (Zebrafish Proteins)
RN  - 0 (beta Catenin)
RN  - 0 (sox17 protein, zebrafish)
RN  - 0 (sox17a protein, Xenopus)
RN  - 0 (sox17b.1 protein, Xenopus)
SB  - IM
MH  - Animals
MH  - Cytoskeletal Proteins/*metabolism
MH  - DNA-Binding Proteins/genetics/*metabolism
MH  - Endosomes/genetics
MH  - Gene Expression Regulation, Developmental
MH  - High Mobility Group Proteins/genetics/*metabolism
MH  - Histocytochemistry
MH  - Homeodomain Proteins/genetics
MH  - Microinjections
MH  - Protein Binding
MH  - Proteins/genetics/*metabolism
MH  - Proto-Oncogene Proteins/*metabolism
MH  - RNA, Messenger/metabolism
MH  - Repressor Proteins/metabolism
MH  - SOXB1 Transcription Factors
MH  - SOXF Transcription Factors
MH  - *Signal Transduction
MH  - *Trans-Activators
MH  - *Transcription Factors
MH  - Wnt Proteins
MH  - Xenopus/embryology
MH  - *Xenopus Proteins
MH  - *Zebrafish Proteins
MH  - beta Catenin
EDAT- 1999/11/05 00:00
MHDA- 1999/11/05 00:01
CRDT- 1999/11/05 00:00
PHST- 1999/11/05 00:00 [pubmed]
PHST- 1999/11/05 00:01 [medline]
PHST- 1999/11/05 00:00 [entrez]
AID - S1097-2765(00)80200-2 [pii]
AID - 10.1016/s1097-2765(00)80200-2 [doi]
PST - ppublish
SO  - Mol Cell. 1999 Oct;4(4):487-98. doi: 10.1016/s1097-2765(00)80200-2.